Knstrn kinetochore-localized astrin/SPAG5 binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Knstrnprovided by RGD
Official Full Name: kinetochore-localized astrin/SPAG5 binding proteinprovided by RGD
Primary source: RGD:1303240
See related: EnsemblRapid:ENSRNOG00000009334 AllianceGenome:RGD:1303240
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SKAP; C15orf23; Traf4af1
Summary: Predicted to enable microtubule plus-end binding activity and protein homodimerization activity. Predicted to be involved in several processes, including cellular response to epidermal growth factor stimulus; mitotic sister chromatid segregation; and regulation of attachment of spindle microtubules to kinetochore. Predicted to be located in microtubule organizing center; plasma membrane; and ruffle. Predicted to be active in kinetochore and microtubule cytoskeleton. Human ortholog(s) of this gene implicated in actinic keratosis and skin squamous cell carcinoma. Orthologous to human KNSTRN (kinetochore localized astrin (SPAG5) binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 194.0), Thymus (RPKM 109.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (126254633..126274412)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (105800762..105820555)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (110618256..110638024)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that Astrin is required for normal mitotic progression in immature Sertoli cells and that the most severe type of testicullar dysplasia in hgn/hgn rats is caused by mitotic cell death of immature Sertoli cells due to lack of Astrin.
Title: Critical roles of Astrin in the mitosis of immature rat Sertoli cells.

Submit: New GeneRIF Correction

General gene information

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Markers

AU019491 (e-PCR)
- UniSTS:159004

RH131720 (e-PCR)
- UniSTS:215003

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables microtubule plus-end binding	IEA Inferred from Electronic Annotation more info
enables microtubule plus-end binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic sister chromatid segregation	IEA Inferred from Electronic Annotation more info
involved_in mitotic sister chromatid segregation	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of attachment of spindle microtubules to kinetochore	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of attachment of spindle microtubules to kinetochore	IEA Inferred from Electronic Annotation more info
involved_in regulation of attachment of spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in regulation of attachment of spindle microtubules to kinetochore	ISS Inferred from Sequence or Structural Similarity more info
involved_in spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle organization	IEA Inferred from Electronic Annotation more info
involved_in spindle organization	ISO Inferred from Sequence Orthology more info
involved_in spindle organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in centriolar satellite	IBA Inferred from Biological aspect of Ancestor more info
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
is_active_in microtubule plus-end	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule plus-end	IEA Inferred from Electronic Annotation more info
located_in microtubule plus-end	ISO Inferred from Sequence Orthology more info
located_in microtubule plus-end	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: small kinetochore-associated protein

Names: TRAF4-associated factor 1; kinastrin; kinetochore-localized astrin-binding protein; putative TRAF4-associated factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004264.1 → NP_001004264.1 small kinetochore-associated protein

See identical proteins and their annotated locations for NP_001004264.1

Status: PROVISIONAL

Source sequence(s)

BC079438

UniProtKB/Swiss-Prot

Q6AXN6

Related

ENSRNOP00000104011.1, ENSRNOT00000131514.1

Conserved Domains (1) summary

cl17190
Location:115 → 192

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

126254633..126274412

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063283710.1 → XP_063139780.1 small kinetochore-associated protein isoform X3
XM_006234757.5 → XP_006234819.1 small kinetochore-associated protein isoform X1

Related

ENSRNOP00000012454.6, ENSRNOT00000012454.7

Conserved Domains (1) summary

cl17190
Location:115 → 192

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_006234758.5 → XP_006234820.1 small kinetochore-associated protein isoform X2

UniProtKB/TrEMBL

A0A8L2Q5L7

Conserved Domains (1) summary

cl17190
Location:57 → 134

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...