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    Ift27 intraflagellar transport 27 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300062, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ift27provided by RGD
    Official Full Name
    intraflagellar transport 27provided by RGD
    Primary source
    RGD:1308703
    See related
    EnsemblRapid:ENSRNOG00000006440 AllianceGenome:RGD:1308703
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rabl4
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including intraciliary transport; smoothened signaling pathway; and spermatogenesis. Predicted to act upstream of or within cochlea development and inner ear receptor cell stereocilium organization. Predicted to be located in centrosome; nucleus; and sperm flagellum. Predicted to be part of intraciliary transport particle B. Predicted to be active in Golgi membrane and cilium. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 19. Orthologous to human IFT27 (intraflagellar transport 27). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 144.4), Thymus (RPKM 78.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ift27 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (111619145..111635129, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (109738622..109754416, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (119393384..119409710, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 2 Neighboring gene uncharacterized LOC102554213 Neighboring gene parvalbumin Neighboring gene neutrophil cytosolic factor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Intraflagellar transporter protein (IFT27), an IFT25 binding partner, is essential for male fertility and spermiogenesis in mice. Zhang Y, et al. Dev Biol, 2017 Dec 1. PMID 28964737, Free PMC Article
    2. Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development. Desai PB, et al. Mech Dev, 2018 Jun. PMID 29626631, Free PMC Article
    3. IFT27 links the BBSome to IFT for maintenance of the ciliary signaling compartment. Eguether T, et al. Dev Cell, 2014 Nov 10. PMID 25446516, Free PMC Article
    4. Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea. May-Simera HL, et al. Development, 2015 Feb 1. PMID 25605782, Free PMC Article
    5. Interaction of mouse TTC30/DYF-1 with multiple intraflagellar transport complex B proteins and KIF17. Howard PW, et al. Exp Cell Res, 2013 Aug 15. PMID 23810713, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cochlea development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inner ear receptor cell stereocilium organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intraciliary transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of intraciliary transport particle B IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intraciliary transport particle B ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm principal piece ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    intraflagellar transport protein 27 homolog
    Names
    RAB, member of RAS oncogene family-like 4
    NP_001123967.1
    XP_038934762.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130495.1 → NP_001123967.1  intraflagellar transport protein 27 homolog

      See identical proteins and their annotated locations for NP_001123967.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473950
      UniProtKB/TrEMBL
      A0A8I5ZYK4, A0A9K3Y729, B4F765, E9PSL5
      Conserved Domains (2) summary
      pfam00071
      Location:7 → 173
      Ras; Ras family
      cl21455
      Location:6 → 172
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      111619145..111635129 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078834.2 → XP_038934762.1  intraflagellar transport protein 27 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYK4
      Related
      ENSRNOP00000008450.6, ENSRNOT00000008450.7
      Conserved Domains (1) summary
      cl38936
      Location:6 → 171
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version

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