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    Tnfaip2 TNF alpha induced protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299339, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tnfaip2provided by RGD
    Official Full Name
    TNF alpha induced protein 2provided by RGD
    Primary source
    RGD:1594556
    See related
    EnsemblRapid:ENSRNOG00000010165 AllianceGenome:RGD:1594556
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable SNARE binding activity. Predicted to be involved in exocyst localization and exocytosis. Predicted to be part of exocyst. Orthologous to human TNFAIP2 (TNF alpha induced protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 112.7), Spleen (RPKM 85.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tnfaip2 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (136297388..136311106)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (130476832..130489914)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (135890869..135903647)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene LBH domain containing 2 Neighboring gene exocyst complex component 3-like 4 Neighboring gene DIRAS family GTPase 3 Neighboring gene uncharacterized LOC120103627 Neighboring gene eukaryotic translation initiation factor 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocyst localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor alpha-induced protein 2
    Names
    tumor necrosis factor, alpha-induced protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433941.1 → NP_001420870.1  tumor necrosis factor alpha-induced protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RNA

    1. NR_197619.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      136297388..136311106
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261786.1 → XP_063117856.1  tumor necrosis factor alpha-induced protein 2 isoform X1

      UniProtKB/TrEMBL
      A6KBR0

    2. XM_039112101.2 → XP_038968029.1  tumor necrosis factor alpha-induced protein 2 isoform X2

      Conserved Domains (1) summary
      cl19885
      Location:157 → 412
      Sec6; Exocyst complex component Sec6

    3. XM_039112102.2 → XP_038968030.1  tumor necrosis factor alpha-induced protein 2 isoform X3

      Conserved Domains (1) summary
      cl19885
      Location:157 → 412
      Sec6; Exocyst complex component Sec6

    4. XM_006240577.5 → XP_006240639.1  tumor necrosis factor alpha-induced protein 2 isoform X1

      UniProtKB/TrEMBL
      A6KBR0, D3ZYQ3
      Conserved Domains (1) summary
      pfam06046
      Location:157 → 688
      Sec6; Exocyst complex component Sec6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001137633.1: Suppressed sequence

      Description
      NM_001137633.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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