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    Ndufb5 NADH:ubiquinone oxidoreductase subunit B5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294964, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ndufb5provided by RGD
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit B5provided by RGD
    Primary source
    RGD:1305909
    See related
    EnsemblRapid:ENSRNOG00000011949 AllianceGenome:RGD:1305909
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial inner membrane and nucleoplasm. Predicted to be part of respiratory chain complex I. Biomarker of acute myocardial infarction. Orthologous to human NDUFB5 (NADH:ubiquinone oxidoreductase subunit B5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 2301.3), Muscle (RPKM 1509.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ndufb5 in Genome Data Viewer
    Location:
    2q24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (117447605..117461943)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (115519248..115533589)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (119139717..119153753)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100797 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene actin-like 6A Neighboring gene mitochondrial ribosomal protein L47 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene ubiquitin specific peptidase 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Diastolic Dysfunction Induced by a High-Fat Diet Is Associated with Mitochondrial Abnormality and Adenosine Triphosphate Levels in Rats. Kang KW, et al. Endocrinol Metab (Seoul), 2015 Dec. PMID 26790384, Free PMC Article
    2. Surgically Metabolic Resection of Pericardial Fat to Ameliorate Myocardial Mitochondrial Dysfunction in Acute Myocardial Infarction Obese Rats. Kang KW, et al. J Korean Med Sci, 2022 Mar 7. PMID 35257523, Free PMC Article
    3. TNF-like weak inducer of apoptosis aggravates left ventricular dysfunction after myocardial infarction in mice. Jarr KU, et al. Mediators Inflamm, 2014. PMID 24692845, Free PMC Article
    4. Accessory subunits are integral for assembly and function of human mitochondrial complex I. Stroud DA, et al. Nature, 2016 Oct 6. PMID 27626371
    5. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. Murray J, et al. J Biol Chem, 2003 Apr 18. PMID 12611891

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
    Names
    NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5
    NP_001099896.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106426.1 → NP_001099896.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

      See identical proteins and their annotated locations for NP_001099896.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473961
      UniProtKB/TrEMBL
      A6IHQ7
      Related
      ENSRNOP00000016051.7, ENSRNOT00000016051.7
      Conserved Domains (1) summary
      pfam09781
      Location:1 → 188
      NDUF_B5; NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      117447605..117461943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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