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    Fgb fibrinogen beta chain [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24366, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fgbprovided by RGD
    Official Full Name
    fibrinogen beta chainprovided by RGD
    Primary source
    RGD:2604
    See related
    EnsemblRapid:ENSRNOG00000007092 AllianceGenome:RGD:2604
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ab1-181; Ab1-216; Ac1-581
    Summary
    Predicted to enable protein-folding chaperone binding activity and structural molecule activity. Predicted to contribute to cell adhesion molecule binding activity and signaling receptor binding activity. Involved in cellular response to interleukin-1 and cellular response to leptin stimulus. Located in blood microparticle. Biomarker of pancreatitis and pulmonary embolism. Human ortholog(s) of this gene implicated in cardiovascular system disease (multiple); congenital afibrinogenemia; and end stage renal disease. Orthologous to human FGB (fibrinogen beta chain). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 21680.9) See more
    Orthologs
    NEW
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    Genomic context

    See Fgb in Genome Data Viewer
    Location:
    2q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (170693966..170700875, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (168394901..168402863, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (182028044..182035026, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene fibrinogen gamma chain Neighboring gene uncharacterized LOC134485930 Neighboring gene fibrinogen alpha chain Neighboring gene pleiotropic regulator 1 Neighboring gene dachsous cadherin-related 2 Neighboring gene uncharacterized LOC120100854

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural molecule activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in blood coagulation, fibrin clot formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in blood coagulation, fibrin clot formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interleukin-1 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to leptin stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in fibrinolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in induction of bacterial agglutination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in plasminogen activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in platelet activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in platelet aggregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptide hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in blood microparticle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of fibrinogen complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of fibrinogen complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in platelet alpha granule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    fibrinogen beta chain
    Names
    beta-fibrinogen
    fibrinogen, B beta polypeptide
    fibrinogen, beta polypeptide
    liver regeneration-related protein LRRG036/LRRG043/LRRG189

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020071.2NP_064456.2  fibrinogen beta chain precursor

      See identical proteins and their annotated locations for NP_064456.2

      Status: PROVISIONAL

      Source sequence(s)
      BC088102
      UniProtKB/Swiss-Prot
      P14480, Q5I0P7, Q7TME5
      UniProtKB/TrEMBL
      A0A8L2UIC0, A6J5V1
      Related
      ENSRNOP00000009813.4, ENSRNOT00000009813.5
      Conserved Domains (2) summary
      pfam08702
      Location:80222
      Fib_alpha; Fibrinogen alpha/beta chain family
      cl00085
      Location:225474
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      170693966..170700875 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)