Klkb1 kallikrein B1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klkb1provided by RGD
Official Full Name: kallikrein B1provided by RGD
Primary source: RGD:67382
See related: EnsemblRapid:ENSRNOG00000014118 AllianceGenome:RGD:67382
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PK; Klk3; Kalp1; KALP15
Summary: Predicted to enable serine-type endopeptidase activity. Involved in liver regeneration. Located in extracellular space. Used to study inflammatory bowel disease. Biomarker of liver cirrhosis. Human ortholog(s) of this gene implicated in lupus nephritis and systemic lupus erythematosus. Orthologous to human KLKB1 (kallikrein B1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 700.7), Adrenal (RPKM 144.3) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q11

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (53690180..53714570)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (46958634..46982054)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (50151127..50175407)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Plasma Kallikrein Contributes to Intracerebral Hemorrhage and Hypertension in Stroke-Prone Spontaneously Hypertensive Rats.
Title: Plasma Kallikrein Contributes to Intracerebral Hemorrhage and Hypertension in Stroke-Prone Spontaneously Hypertensive Rats.
findings suggest for the first time that higher plasma prekallikrein activity may serve as an indicator for predicting high BP and left ventricular hypertrophy in diabetic and hypertensive conditions
Title: Changes in plasma prekallikrein activity, blood pressure, and left ventricular thickness in hypertensive and normotensive diabetic rats.

Submit: New GeneRIF Correction

General gene information

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Markers

D16MGH5 (e-PCR)
- UniSTS:121111

D16Wox13 (e-PCR)
- UniSTS:118127

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in fibrinolysis	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in liver regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in plasminogen activation	IEA Inferred from Electronic Annotation more info
involved_in plasminogen activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibrinolysis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fibrinolysis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: plasma kallikrein

Names: fletcher factor; kallikrein B, plasma 1; kininogenin; plasma prekallikrein

NP_036857.2

EC 3.4.21.34

XP_006253183.1

EC 3.4.21.34

XP_008769475.2

EC 3.4.21.34

XP_063131126.1

EC 3.4.21.34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012725.2 → NP_036857.2 plasma kallikrein precursor

See identical proteins and their annotated locations for NP_036857.2

Status: PROVISIONAL

Source sequence(s)

BC089815

UniProtKB/Swiss-Prot

P14272

UniProtKB/TrEMBL

A6JPR7, F7FQ32, Q5FVS2

Related

ENSRNOP00000019237.3, ENSRNOT00000019237.7

Conserved Domains (3) summary

smart00223
Location:21 → 104

APPLE; APPLE domain

smart00020
Location:390 → 621

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:391 → 621

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

53690180..53714570

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006253121.5 → XP_006253183.1 plasma kallikrein isoform X1

UniProtKB/Swiss-Prot

P14272

Conserved Domains (3) summary

smart00223
Location:21 → 104

APPLE; APPLE domain

smart00020
Location:377 → 608

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:378 → 608

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_063275056.1 → XP_063131126.1 plasma kallikrein isoform X2
XM_008771253.3 → XP_008769475.2 plasma kallikrein isoform X3

UniProtKB/TrEMBL

A6JPR8

Related

ENSRNOP00000108529.1, ENSRNOT00000121109.1

Conserved Domains (3) summary

smart00223
Location:49 → 132

APPLE; APPLE domain

cd00190
Location:329 → 559

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

cl00112
Location:14 → 42

PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...