Comp cartilage oligomeric matrix protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Compprovided by RGD
Official Full Name: cartilage oligomeric matrix proteinprovided by RGD
Primary source: RGD:2378
See related: EnsemblRapid:ENSRNOG00000048472 AllianceGenome:RGD:2378
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables fibronectin binding activity and vitamin D binding activity. An extracellular matrix structural constituent. Predicted to be involved in cartilage homeostasis; negative regulation of apoptotic process; and protein homooligomerization. Predicted to act upstream of or within several processes, including BMP signaling pathway; cartilage development; and vasculature development. Located in collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in carpal tunnel syndrome 2; multiple epiphyseal dysplasia 1; osteochondrodysplasia; and pseudoachondroplasia. Orthologous to human COMP (cartilage oligomeric matrix protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 60.4), Muscle (RPKM 22.9) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (19081172..19089548, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (19047206..19055584, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (20798437..20807070, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Duchenne muscular dystrophy trajectory in R-DMDdel52 preclinical rat model identifies COMP as biomarker of fibrosis.
Title: Duchenne muscular dystrophy trajectory in R-DMDdel52 preclinical rat model identifies COMP as biomarker of fibrosis.
A Study on COMP and CTX-II as Molecular Markers for the Diagnosis of Intervertebral Disc Degeneration.
Title: A Study on COMP and CTX-II as Molecular Markers for the Diagnosis of Intervertebral Disc Degeneration.
COMP-prohibitin 2 interaction in mitochondria plays an important role in maintaining the contractile phenotype of Vascular smooth muscle cells by regulating mitochondrial oxidative phosphorylation.
Title: COMP-prohibitin 2 interaction maintains mitochondrial homeostasis and controls smooth muscle cell identity.
COMP could normally have a protective role against PASMC phenotype switching
Title: Hypoxia decrease expression of cartilage oligomeric matrix protein to promote phenotype switching of pulmonary arterial smooth muscle cells.
these findings revealed the essential role of COMP in retarding the development of vascular aging and vascular smooth muscle cell senescence.
Title: Cartilage oligomeric matrix protein prevents vascular aging and vascular smooth muscle cells senescence.
COMP-Ang1-stimulated proliferation, differentiation, and migration of progenitor cells may involve the Tie-2-mediated activation of p38 MAPK and PI3K/Akt pathways
Title: COMP-angiopoietin 1 increases proliferation, differentiation, and migration of stem-like cells through Tie-2-mediated activation of p38 MAPK and PI3K/Akt signal transduction pathways.
results suggest the potential importance of COMP-Ang1 as a new therapy for impaired bone formation that is associated with diabetes and advanced age
Title: COMP-Ang1 inhibits apoptosis as well as improves the attenuated osteogenic differentiation of mesenchymal stem cells induced by advanced glycation end products.
The presence of cleaved apoptosis inducing factor (tAIF) and the absence of activated caspases indicated that retention of D469del-COMP triggers cell death in chondrocytes by necroptosis, a caspase-independent programmed necrosis.
Title: D469del-COMP retention in chondrocytes stimulates caspase-independent necroptosis.
Cartilage oligomeric matrix protein is a novel inhibitor of vascular smooth muscle calcification.
Title: Cartilage oligomeric matrix protein inhibits vascular smooth muscle calcification by interacting with bone morphogenetic protein-2.
Overexpression of COMP markedly suppressed PDGF-BB-elicited VSMC dedifferentiation. Alpha(7)beta(1) integrin is a potential receptor for COMP.
Title: Cartilage oligomeric matrix protein maintains the contractile phenotype of vascular smooth muscle cells by interacting with alpha(7)beta(1) integrin.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables BMP binding	IEA Inferred from Electronic Annotation more info
enables BMP binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables collagen binding	IEA Inferred from Electronic Annotation more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables extracellular matrix structural constituent	IDA Inferred from Direct Assay more info	PubMed
enables fibronectin binding	IDA Inferred from Direct Assay more info	PubMed
enables heparan sulfate proteoglycan binding	IEA Inferred from Electronic Annotation more info
enables heparan sulfate proteoglycan binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables proteoglycan binding	ISO Inferred from Sequence Orthology more info
enables vitamin D binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in artery morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within artery morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood coagulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone growth	ISO Inferred from Sequence Orthology more info
involved_in bone mineralization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone mineralization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cartilage development	ISO Inferred from Sequence Orthology more info
involved_in cartilage homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cartilage homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cartilage homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cellular senescence	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in chondrocyte development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chondrocyte development	ISO Inferred from Sequence Orthology more info
involved_in chondrocyte proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chondrocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in collagen fibril organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within collagen fibril organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endochondral bone growth	ISO Inferred from Sequence Orthology more info
involved_in growth plate cartilage development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within growth plate cartilage development	ISO Inferred from Sequence Orthology more info
involved_in limb development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within limb development	ISO Inferred from Sequence Orthology more info
involved_in limb development	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in musculoskeletal movement	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within musculoskeletal movement	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hemostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of hemostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ossification	ISO Inferred from Sequence Orthology more info
involved_in platelet aggregation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within platelet aggregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chondrocyte proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of chondrocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein processing	ISO Inferred from Sequence Orthology more info
involved_in protein secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of bone mineralization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in response to unfolded protein	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to unfolded protein	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in skin development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skin development	ISO Inferred from Sequence Orthology more info
involved_in tendon development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tendon development	ISO Inferred from Sequence Orthology more info
involved_in vascular associated smooth muscle cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vascular associated smooth muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in vascular associated smooth muscle contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vascular associated smooth muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cartilage oligomeric matrix protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012834.2 → NP_036966.2 cartilage oligomeric matrix protein precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

P35444

UniProtKB/TrEMBL

A6KA56, M0RBU0

Related

ENSRNOP00000067037.1, ENSRNOT00000072536.4

Conserved Domains (8) summary

smart00179
Location:178 → 216

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:125 → 160

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

sd00001
Location:395 → 416

TSP3; TSP3 repeat_short [structural motif]

sd00002
Location:299 → 334

TSP3; TSP3 repeat_long [structural motif]

cd16077
Location:29 → 71

TSP-5cc; Coiled coil region of thrombospondin-5 (TSP-5)

pfam02412
Location:299 → 334

TSP_3; Thrombospondin type 3 repeat

pfam05735
Location:544 → 741

TSP_C; Thrombospondin C-terminal region

NF033845
Location:311 → 513

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

19081172..19089548 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006252822.5 → XP_006252884.1 cartilage oligomeric matrix protein isoform X1

UniProtKB/TrEMBL

A0A8I6A7Z1

Conserved Domains (6) summary

smart00179
Location:74 → 112

EGF_CA; Calcium-binding EGF-like domain

sd00001
Location:291 → 312

TSP3; TSP3 repeat_short [structural motif]

sd00002
Location:195 → 230

TSP3; TSP3 repeat_long [structural motif]

pfam00008
Location:25 → 56

EGF; EGF-like domain

pfam02412
Location:196 → 230

TSP_3; Thrombospondin type 3 repeat

pfam05735
Location:440 → 637

TSP_C; Thrombospondin C-terminal region