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    Rnf227 ring finger protein 227 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497935, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rnf227provided by RGD
    Official Full Name
    ring finger protein 227provided by RGD
    Primary source
    RGD:1563441
    See related
    EnsemblRapid:ENSRNOG00000021540 AllianceGenome:RGD:1563441
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563441
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Orthologous to human RNF227 (ring finger protein 227). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 93.9), Testes (RPKM 10.9) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rnf227 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54559862..54561823)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54061054..54063015)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (55940533..55941205)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene centrobin, centriole duplication and spindle assembly protein Neighboring gene trafficking protein particle complex subunit 1 Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 3 Neighboring gene chromodomain helicase DNA binding protein 3 Neighboring gene small Cajal body-specific RNA 21 Neighboring gene N(alpha)-acetyltransferase 38, NatC auxiliary subunit Neighboring gene cytochrome b5 domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RING finger protein 227

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126292.2 → NP_001119764.1  RING finger protein 227

      See identical proteins and their annotated locations for NP_001119764.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      B2BKZ7, B2BKZ9
      Related
      ENSRNOP00000012061.3, ENSRNOT00000012061.7
      Conserved Domains (3) summary
      cd00162
      Location:18 → 80
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      pfam15451
      Location:117 → 187
      DUF4632; Domain of unknown function (DUF4632)
      cl17238
      Location:17 → 81
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      54559862..54561823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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