Ankrd2 ankyrin repeat domain 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ankrd2provided by RGD
Official Full Name: ankyrin repeat domain 2provided by RGD
Primary source: RGD:1305104
See related: EnsemblRapid:ENSRNOG00000013840 AllianceGenome:RGD:1305104
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; protein kinase B binding activity; and titin binding activity. Predicted to be involved in negative regulation of myoblast differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including negative regulation of myotube differentiation; regulation of gene expression; and skeletal muscle cell differentiation. Predicted to be located in several cellular components, including I band; PML body; and euchromatin. Predicted to be active in nucleus. Orthologous to human ANKRD2 (ankyrin repeat domain 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 522.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (250796419..250805867)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (240847111..240856563)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (261281859..261291307)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data are not consistent with the proposal that Ankrd 2, per se, or pAnkrd 2-Ser99 mediates stretch-induced signaling in skeletal muscle, dissociating from titin and translocating to the nucleus, because the majority of these forms of Ankrd 2 are already free in the cytosol.
Title: Characterization of muscle ankyrin repeat proteins in human skeletal muscle.
Ankrd2 does not bind the human androgen receptor (AR) or alter testosterone-induced changes in reporter gene activity, indicating that it is not a direct transcriptional effector for the AR.
Title: Ankrd1 is a transcriptional repressor for the androgen receptor that is downregulated by testosterone.
assignment of Ankrd2 to rat chromosome 1q51-q53.
Title: Assignment of the murine ankyrin-repeated protein gene (Ankrd2) to mouse chromosome 19C3-->D1 and rat chromosome 1q51-->q53 by fluorescence in situ hybridization.

Submit: New GeneRIF Correction

General gene information

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Markers

AA849895 (e-PCR)
- UniSTS:261140

AI764749 (e-PCR)
- UniSTS:248204

Ankrd2 (e-PCR), detects polymorphism
- UniSTS:502938

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein kinase B binding	ISO Inferred from Sequence Orthology more info
enables titin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of myotube differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of myotube differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of myoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in I band	ISO Inferred from Sequence Orthology more info
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in euchromatin	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in myofibril	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in sarcomere	ISO Inferred from Sequence Orthology more info
located_in sarcoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ankyrin repeat domain-containing protein 2

Names: ankyrin repeat domain 2 (stretch responsive muscle)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107589.1 → NP_001101059.1 ankyrin repeat domain-containing protein 2

See identical proteins and their annotated locations for NP_001101059.1

Status: PROVISIONAL

Source sequence(s)

CH473986

UniProtKB/TrEMBL

A6JHA1, D3ZM27

Related

ENSRNOP00000087179.2, ENSRNOT00000109708.2

Conserved Domains (5) summary

cd00204
Location:144 → 269

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:154 → 246

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:120 → 170

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:231 → 289

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:184 → 213

ANK; ANK repeat [structural motif]