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    Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304135, updated on 27-Nov-2024

    Summary

    Official Symbol
    Adamts5provided by RGD
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif, 5provided by RGD
    Primary source
    RGD:735196
    See related
    EnsemblRapid:ENSRNOG00000057794 AllianceGenome:RGD:735196
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including heparin binding activity; identical protein binding activity; and metalloendopeptidase activity. Predicted to be involved in several processes, including heart development; myoblast fusion; and negative regulation of cold-induced thermogenesis. Predicted to act upstream of or within defense response to bacterium. Predicted to be located in extracellular space. Predicted to be active in extracellular matrix. Used to study osteoarthritis. Biomarker of degenerative disc disease; mucopolysaccharidosis VI; and osteoarthritis. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to human ADAMTS5 (ADAM metallopeptidase with thrombospondin type 1 motif 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 124.2), Heart (RPKM 91.0) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Adamts5 in Genome Data Viewer
    Location:
    11q11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (38486945..38533516, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (25000627..25047205, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (25411174..25456639, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene nascent polypeptide associated complex subunit alpha, pseudogene 1 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 1 Neighboring gene uncharacterized LOC102552725 Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables extracellular matrix binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in aortic valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocardial cushion morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in myoblast fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pulmonary valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 5
    Names
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198761.2NP_942056.2  A disintegrin and metalloproteinase with thrombospondin motifs 5 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6JL67, G3V673, Q6TY19
      Related
      ENSRNOP00000068781.1, ENSRNOT00000085444.3
      Conserved Domains (6) summary
      smart00209
      Location:567619
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:268470
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:729849
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam01562
      Location:61181
      Pep_M12B_propep; Reprolysin family propeptide
      pfam17771
      Location:484551
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:876927
      TSP1_ADAMTS; Thrombospondin type 1 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      38486945..38533516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)