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    Atad5 ATPase family, AAA domain containing 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303348, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Atad5provided by RGD
    Official Full Name
    ATPase family, AAA domain containing 5provided by RGD
    Primary source
    RGD:1561464
    See related
    EnsemblRapid:ENSRNOG00000021903 AllianceGenome:RGD:1561464
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561464
    Summary
    Predicted to enable DNA binding activity and DNA clamp unloader activity. Predicted to be involved in several processes, including negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of DNA replication; and positive regulation of cell cycle G2/M phase transition. Predicted to act upstream of or within several processes, including intracellular signal transduction; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; and positive regulation of B cell activation. Predicted to be part of Elg1 RFC-like complex. Predicted to be active in nucleus. Orthologous to human ATAD5 (ATPase family AAA domain containing 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 103.6), Spleen (RPKM 72.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atad5 in Genome Data Viewer
    Location:
    10q25
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (65568569..65616379)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (65070682..65118489)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (67427042..67475825)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene SUZ12 polycomb repressive complex 2 subunit Neighboring gene ribosomal protein L12, pseudogene 6 Neighboring gene cytokine receptor-like factor 3 Neighboring gene phosphoglycerate mutase 1, pseudogene 3 Neighboring gene transcription elongation factor, mitochondrial

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of genes potentially involved in the increased risk of malignancy in NF1-microdeleted patients. Pasmant E, et al. Mol Med, 2011 Jan-Feb. PMID 20844836, Free PMC Article
    2. ATAD5 deficiency decreases B cell division and Igh recombination. Zanotti KJ, et al. J Immunol, 2015 Jan 1. PMID 25404367, Free PMC Article
    3. Predisposition to cancer caused by genetic and functional defects of mammalian Atad5. Bell DW, et al. PLoS Genet, 2011 Aug. PMID 21901109, Free PMC Article
    4. ATAD5 regulates the lifespan of DNA replication factories by modulating PCNA level on the chromatin. Lee KY, et al. J Cell Biol, 2013 Jan 7. PMID 23277426, Free PMC Article
    5. Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. Ishii H, et al. Proc Natl Acad Sci U S A, 2005 Jul 5. PMID 15983387, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA clamp unloader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA clamp unloader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA clamp unloading IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of isotype switching ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell cycle G2/M phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of isotype switching to IgG isotypes ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of mitotic cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within signal transduction in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Elg1 RFC-like complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATPase family AAA domain-containing protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      65568569..65616379
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_220750.11 → XP_220750.6  ATPase family AAA domain-containing protein 5 isoform X1

      See identical proteins and their annotated locations for XP_220750.6

      UniProtKB/TrEMBL
      A6HHA2, D4A058
      Related
      ENSRNOP00000028975.5, ENSRNOT00000035642.8
      Conserved Domains (1) summary
      cl21455
      Location:1121 → 1166
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_039087647.2 → XP_038943575.1  ATPase family AAA domain-containing protein 5 isoform X2

      UniProtKB/TrEMBL
      A6HHA2
      Related
      ENSRNOP00000099936.1, ENSRNOT00000133075.1
      Conserved Domains (1) summary
      PRK04195
      Location:1045 → 1348
      PRK04195; replication factor C large subunit; Provisional

    3. XM_006246963.5 → XP_006247025.1  ATPase family AAA domain-containing protein 5 isoform X3

      See identical proteins and their annotated locations for XP_006247025.1

      UniProtKB/TrEMBL
      A6HHA2
      Related
      ENSRNOP00000108956.1, ENSRNOT00000136626.1
      Conserved Domains (1) summary
      cl21455
      Location:1058 → 1103
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. XR_010055697.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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