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    Shc2 SHC adaptor protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314612, updated on 9-Dec-2024

    Summary

    Official Symbol
    Shc2provided by RGD
    Official Full Name
    SHC adaptor protein 2provided by RGD
    Primary source
    RGD:1307137
    See related
    EnsemblRapid:ENSRNOG00000008030 AllianceGenome:RGD:1307137
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be active in plasma membrane. Orthologous to human SHC2 (SHC adaptor protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 53.8), Brain (RPKM 49.5) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Shc2 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10717320..10739539)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (10066705..10088926)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12948952..12971174)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene mucosal vascular addressin cell adhesion molecule 1 Neighboring gene CIMAP1 family member D Neighboring gene C2 calcium-dependent domain containing 4C Neighboring gene uncharacterized LOC134479817

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    SHC-transforming protein 2
    Names
    SH2 domain protein C2
    SHC (Src homology 2 domain containing) transforming protein 2
    protein Sck
    src homology 2 domain-containing transforming protein C2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108065.1NP_001101535.1  SHC-transforming protein 2

      See identical proteins and their annotated locations for NP_001101535.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474029
      UniProtKB/Swiss-Prot
      O70142
      UniProtKB/TrEMBL
      A6K8Z6
      Related
      ENSRNOP00000010714.5, ENSRNOT00000010714.7
      Conserved Domains (2) summary
      cd09925
      Location:470573
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:116285
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10717320..10739539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)