Myh14 myosin heavy chain 14 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myh14provided by RGD
Official Full Name: myosin heavy chain 14provided by RGD
Primary source: RGD:1306821
See related: EnsemblRapid:ENSRNOG00000020014 AllianceGenome:RGD:1306821
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including ATP binding activity; actin filament binding activity; and microfilament motor activity. Predicted to be involved in several processes, including neuronal action potential; sensory perception of sound; and vocalization behavior. Predicted to act upstream of or within actin filament-based movement. Predicted to be located in several cellular components, including brush border; myosin II filament; and stress fiber. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 4A and sensorineural hearing loss. Orthologous to human MYH14 (myosin heavy chain 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 207.8), Heart (RPKM 131.1) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (104232778..104295369, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (95096266..95158861, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (100608975..100671086, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Got97 (e-PCR)
- UniSTS:115218

RH142730 (e-PCR)
- UniSTS:231977

AW532989 (e-PCR)
- UniSTS:245598

AU048673 (e-PCR)
- UniSTS:145123

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to actin filament binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to microfilament motor activity	ISO Inferred from Sequence Orthology more info
enables microfilament motor activity	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin filament-based movement	ISO Inferred from Sequence Orthology more info
involved_in actomyosin structure organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actomyosin structure organization	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in vocalization behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actomyosin	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in brush border	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin II complex	ISO Inferred from Sequence Orthology more info
located_in myosin II filament	ISO Inferred from Sequence Orthology more info
part_of myosin complex	ISO Inferred from Sequence Orthology more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myosin-14

Names: myosin, heavy chain 14, non-muscle; myosin, heavy polypeptide 14

NP_001094160.1

EC 5.6.1.8

XP_006229118.1

EC 5.6.1.8

XP_006229119.1

EC 5.6.1.8

XP_063117993.1

EC 5.6.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100690.1 → NP_001094160.1 myosin-14

See identical proteins and their annotated locations for NP_001094160.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A0G2K3H1

Related

ENSRNOP00000089689.2, ENSRNOT00000094017.2

Conserved Domains (3) summary

cd14930
Location:115 → 792

MYSc_Myh14_mammals; class II myosin heavy chain 14 motor domain

pfam00063
Location:104 → 792

Myosin_head; Myosin head (motor domain)

pfam01576
Location:869 → 1949

Myosin_tail_1; Myosin tail

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

104232778..104295369 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006229057.5 → XP_006229119.1 myosin-14 isoform X2

UniProtKB/TrEMBL

A0A0G2K3H1

Conserved Domains (3) summary

cd14930
Location:115 → 784

MYSc_Myh14_mammals; class II myosin heavy chain 14 motor domain

pfam00063
Location:104 → 784

Myosin_head; Myosin head (motor domain)

pfam01576
Location:861 → 1941

Myosin_tail_1; Myosin tail
XM_006229056.5 → XP_006229118.1 myosin-14 isoform X1

See identical proteins and their annotated locations for XP_006229118.1

UniProtKB/TrEMBL

A0A0G2K3H1

Conserved Domains (3) summary

cd14930
Location:115 → 792

MYSc_Myh14_mammals; class II myosin heavy chain 14 motor domain

pfam00063
Location:104 → 792

Myosin_head; Myosin head (motor domain)

pfam01576
Location:869 → 1949

Myosin_tail_1; Myosin tail
XM_063261923.1 → XP_063117993.1 myosin-14 isoform X2

Related

ENSRNOP00000112760.1, ENSRNOT00000139210.1