Agfg1 ArfGAP with FG repeats 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Agfg1provided by RGD
Official Full Name: ArfGAP with FG repeats 1provided by RGD
Primary source: RGD:1560041
See related: EnsemblRapid:ENSRNOG00000015619 AllianceGenome:RGD:1560041
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA binding activity; GTPase activator activity; and metal ion binding activity. Predicted to be involved in acrosome assembly; intermediate filament organization; and spermatid nucleus differentiation. Predicted to be located in cell projection; intracellular membrane-bounded organelle; and neuronal cell body. Predicted to be active in cytoplasmic vesicle. Orthologous to human AGFG1 (ArfGAP with FG repeats 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 242.7), Brain (RPKM 224.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q34

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (91572962..91630688)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (84124845..84182615)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (88607508..88663486)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acrosome assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within acrosome assembly	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intermediate filament organization	ISO Inferred from Sequence Orthology more info
involved_in spermatid nucleus differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatid nucleus differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell projection	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: arf-GAP domain and FG repeat-containing protein 1

Names: HIV-1 Rev-binding protein homolog; arf-GAP domain and FG repeats-containing protein 1; nucleoporin-like protein RIP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135596.2 → NP_001129068.1 arf-GAP domain and FG repeat-containing protein 1

See identical proteins and their annotated locations for NP_001129068.1

Status: VALIDATED

Source sequence(s)

FM032550, FM042993, FM069945, FM075043, FM099288, FM122674, FN806187, JAXUCZ010000009

UniProtKB/Swiss-Prot

Q4KLH5

Related

ENSRNOP00000111045.1, ENSRNOT00000021309.9

Conserved Domains (3) summary

PHA03247
Location:409 → 559

PHA03247; large tegument protein UL36; Provisional

COG5347
Location:8 → 309

COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]

cd08857
Location:13 → 128

ArfGap_AGFG1; ArfGAP domain of AGFG1 (ArfGAP domain and FG repeat-containing protein 1)