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    Sppl2a signal peptide peptidase-like 2A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311401, updated on 27-Nov-2024

    Summary

    Official Symbol
    Sppl2aprovided by RGD
    Official Full Name
    signal peptide peptidase-like 2Aprovided by RGD
    Primary source
    RGD:1563001
    See related
    EnsemblRapid:ENSRNOG00000011652 AllianceGenome:RGD:1563001
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563001
    Summary
    Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Predicted to be involved in membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; and regulation of immune response. Predicted to be located in late endosome membrane and plasma membrane. Predicted to be active in bounding membrane of organelle and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human SPPL2A (signal peptide peptidase like 2A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 240.4), Lung (RPKM 216.7) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Sppl2a in Genome Data Viewer
    Location:
    3q36
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (134602684..134646752, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (114149337..114193408, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (119361651..119405453, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 50 Neighboring gene transient receptor potential cation channel, subfamily M, member 7 Neighboring gene uncharacterized LOC134486145 Neighboring gene mitochondrial fission regulator 1-like Neighboring gene adaptor related protein complex 4 subunit epsilon 1 Neighboring gene uncharacterized LOC134486146 Neighboring gene biliverdin reductase A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aspartic endopeptidase activity, intramembrane cleaving IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables aspartic endopeptidase activity, intramembrane cleaving ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane protein intracellular domain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane protein proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in membrane protein proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of immune response ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi-associated vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi-associated vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasmic side of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic side of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lumenal side of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lumenal side of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    signal peptide peptidase-like 2A
    NP_001101240.1
    XP_006234982.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107770.1NP_001101240.1  signal peptide peptidase-like 2A precursor

      See identical proteins and their annotated locations for NP_001101240.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473949
      UniProtKB/TrEMBL
      A6HPZ6, D3ZNG3
      Related
      ENSRNOP00000015568.6, ENSRNOT00000015568.8
      Conserved Domains (2) summary
      pfam04258
      Location:214499
      Peptidase_A22B; Signal peptide peptidase
      cl10459
      Location:44163
      Peptidases_S8_S53; Peptidase domain in the S8 and S53 families

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      134602684..134646752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234920.5XP_006234982.1  signal peptide peptidase-like 2A isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYA3
      Related
      ENSRNOP00000070578.2, ENSRNOT00000090355.3
      Conserved Domains (2) summary
      pfam04258
      Location:214517
      Peptidase_A22B; Signal peptide peptidase
      cl10459
      Location:44163
      Peptidases_S8_S53; Peptidase domain in the S8 and S53 families