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    Tmem38b transmembrane protein 38B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362521, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tmem38bprovided by RGD
    Official Full Name
    transmembrane protein 38Bprovided by RGD
    Primary source
    RGD:1305703
    See related
    EnsemblRapid:ENSRNOG00000028063 AllianceGenome:RGD:1305703
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305703
    Summary
    Predicted to enable potassium channel activity. Predicted to be involved in regulation of release of sequestered calcium ion into cytosol. Predicted to act upstream of or within several processes, including cellular response to caffeine; lung development; and regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 14. Orthologous to human TMEM38B (transmembrane protein 38B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 344.8), Liver (RPKM 180.8) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tmem38b in Genome Data Viewer
    Location:
    5q24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (73255662..73291383)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (68460304..68496026)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (70639156..70675055)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene fukutin Neighboring gene uncharacterized LOC134478974 Neighboring gene TAL bHLH transcription factor 2 Neighboring gene placenta expressed transcript 1, pseudogene 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene calcineurin-like EF-hand protein 1 like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to caffeine ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within endoplasmic reticulum organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within extracellular matrix constituent secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lung alveolus development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lung epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ossification ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phospholipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of release of sequestered calcium ion into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within release of sequestered calcium ion into cytosol by endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within secretion by lung epithelial cell involved in lung growth ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    trimeric intracellular cation channel type B
    Names
    TRIC-B
    TRICB

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014191.1NP_001014213.1  trimeric intracellular cation channel type B

      See identical proteins and their annotated locations for NP_001014213.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079336
      UniProtKB/Swiss-Prot
      Q68FV1
      UniProtKB/TrEMBL
      A6KDP9
      Related
      ENSRNOP00000033050.3, ENSRNOT00000034570.5
      Conserved Domains (1) summary
      pfam05197
      Location:39222
      TRIC; TRIC channel

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      73255662..73291383
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)