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    Heatr1 HEAT repeat containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361262, updated on 27-Nov-2024

    Summary

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    Symbol
    Heatr1provided by RGD
    Full Name
    HEAT repeat containing 1provided by RGD
    Primary source
    RGD:1564769
    See related
    EnsemblRapid:ENSRNOG00000047594 AllianceGenome:RGD:1564769
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Heatr1l1; RGD1564769
    Summary
    Predicted to enable snoRNA binding activity. Predicted to be involved in several processes, including maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); positive regulation of RNA metabolic process; and protein localization to nucleolus. Predicted to be located in fibrillar center and mitochondrion. Predicted to be part of 90S preribosome; small-subunit processome; and t-UTP complex. Human ortholog(s) of this gene implicated in pancreatic ductal carcinoma. Orthologous to human HEATR1 (HEAT repeat containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 183.9), Thymus (RPKM 109.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Heatr1 in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (62745008..62785609, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (58053288..58093895, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (66446135..66488303)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene anillin, actin binding protein-like 1 Neighboring gene galectin 8 Neighboring gene actinin alpha 2 Neighboring gene transfer RNA serine (anticodon AGA) 47 Neighboring gene uncharacterized LOC120097915 Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. HEATR1 Negatively Regulates Akt to Help Sensitize Pancreatic Cancer Cells to Chemotherapy. Liu T, et al. Cancer Res, 2016 Feb 1. PMID 26676747, Free PMC Article
    2. Glioma-associated antigen HEATR1 induces functional cytotoxic T lymphocytes in patients with glioma. Wu ZB, et al. J Immunol Res, 2014. PMID 25126583, Free PMC Article
    3. Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription in human cells. Prieto JL, et al. Genes Dev, 2007 Aug 15. PMID 17699751, Free PMC Article
    4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of rRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of 90S preribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of t-UTP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    HEAT repeat-containing protein 1
    Names
    HEAT repeat containing 1-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108418.2 → NP_001101888.1  HEAT repeat-containing protein 1

      See identical proteins and their annotated locations for NP_001101888.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6KN33, D3ZL86, M0R3U0
      Related
      ENSRNOP00000064012.3, ENSRNOT00000070825.4
      Conserved Domains (3) summary
      smart01036
      Location:1856 → 2009
      BP28CT; BP28CT (NUC211) domain
      pfam12397
      Location:238 → 354
      U3snoRNP10; U3 small nucleolar RNA-associated protein 10
      sd00044
      Location:1643 → 1678
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      62745008..62785609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600630.3 → XP_017456119.1  HEAT repeat-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A6KN33, D3ZL86, M0R3U0
      Conserved Domains (3) summary
      smart01036
      Location:1856 → 2009
      BP28CT; BP28CT (NUC211) domain
      pfam12397
      Location:238 → 354
      U3snoRNP10; U3 small nucleolar RNA-associated protein 10
      sd00044
      Location:1643 → 1678
      HEAT; HEAT repeat [structural motif]

    2. XM_017600631.3 → XP_017456120.1  HEAT repeat-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A6KN33, D3ZL86, M0R3U0
      Conserved Domains (3) summary
      smart01036
      Location:1856 → 2009
      BP28CT; BP28CT (NUC211) domain
      pfam12397
      Location:238 → 354
      U3snoRNP10; U3 small nucleolar RNA-associated protein 10
      sd00044
      Location:1643 → 1678
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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