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    Znrf1 zinc and ring finger 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690769, updated on 3-Dec-2024

    Summary

    Official Symbol
    Znrf1provided by RGD
    Official Full Name
    zinc and ring finger 1provided by RGD
    Primary source
    RGD:1592195
    See related
    EnsemblRapid:ENSRNOG00000019028 AllianceGenome:RGD:1592195
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of autophagosome-lysosome fusion; positive regulation of toll-like receptor 4 signaling pathway; and protein K48-linked ubiquitination. Predicted to be located in cytosol and endosome. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and membrane. Orthologous to human ZNRF1 (zinc and ring finger 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 174.1), Muscle (RPKM 172.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Znrf1 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (56403816..56490901)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (39496414..39581600)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (43750205..43834962)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 59 Neighboring gene 60S ribosomal protein L29-like Neighboring gene uncharacterized LOC120098630 Neighboring gene uncharacterized LOC134483371 Neighboring gene lactate dehydrogenase D Neighboring gene zinc finger protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase ZNRF1
    Names
    zinc and ring finger 1, E3 ubiquitin protein ligase
    NP_001388008.1
    NP_001388009.1
    XP_006255712.1
    XP_006255713.1
    XP_006255714.1
    XP_038954193.1
    XP_038954194.1
    XP_038954195.1
    XP_038954196.1
    XP_063134365.1
    XP_063134366.1
    XP_063134367.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401079.1NP_001388008.1  E3 ubiquitin-protein ligase ZNRF1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IZ93, D3ZIQ9
      Related
      ENSRNOP00000093092.2, ENSRNOT00000095580.2
    2. NM_001401080.1NP_001388009.1  E3 ubiquitin-protein ligase ZNRF1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IZ93, D3ZIQ9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      56403816..56490901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278295.1XP_063134365.1  E3 ubiquitin-protein ligase ZNRF1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUZ1
    2. XM_006255650.4XP_006255712.1  E3 ubiquitin-protein ligase ZNRF1 isoform X1

      See identical proteins and their annotated locations for XP_006255712.1

      UniProtKB/TrEMBL
      A0A8I5ZUZ1
      Conserved Domains (1) summary
      cd16694
      Location:216261
      mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins
    3. XM_006255652.4XP_006255714.1  E3 ubiquitin-protein ligase ZNRF1 isoform X1

      See identical proteins and their annotated locations for XP_006255714.1

      UniProtKB/TrEMBL
      A0A8I5ZUZ1
      Conserved Domains (1) summary
      cd16694
      Location:216261
      mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins
    4. XM_006255651.4XP_006255713.1  E3 ubiquitin-protein ligase ZNRF1 isoform X1

      See identical proteins and their annotated locations for XP_006255713.1

      UniProtKB/TrEMBL
      A0A8I5ZUZ1
      Related
      ENSRNOP00000083192.1, ENSRNOT00000117072.2
      Conserved Domains (1) summary
      cd16694
      Location:216261
      mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins
    5. XM_039098265.2XP_038954193.1  E3 ubiquitin-protein ligase ZNRF1 isoform X2

      UniProtKB/TrEMBL
      A6IZ93, D3ZIQ9
      Conserved Domains (1) summary
      cd16694
      Location:182227
      mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins
    6. XM_063278296.1XP_063134366.1  E3 ubiquitin-protein ligase ZNRF1 isoform X2

      UniProtKB/TrEMBL
      A6IZ93, D3ZIQ9
    7. XM_039098266.2XP_038954194.1  E3 ubiquitin-protein ligase ZNRF1 isoform X3

    8. XM_039098268.2XP_038954196.1  E3 ubiquitin-protein ligase ZNRF1 isoform X5

    9. XM_039098267.2XP_038954195.1  E3 ubiquitin-protein ligase ZNRF1 isoform X4

    10. XM_063278297.1XP_063134367.1  E3 ubiquitin-protein ligase ZNRF1 isoform X6