Rbms3 RNA binding motif, single stranded interacting protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rbms3provided by RGD
Official Full Name: RNA binding motif, single stranded interacting protein 3provided by RGD
Primary source: RGD:1588240
See related: EnsemblRapid:ENSRNOG00000025881 AllianceGenome:RGD:1588240
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable mRNA 3'-UTR AU-rich region binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Predicted to be involved in defense response to tumor cell; negative regulation of canonical Wnt signaling pathway; and regulation of gene expression. Predicted to act upstream of or within positive regulation of translation. Predicted to be located in cytoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol and nucleus. Orthologous to human RBMS3 (RNA binding motif single stranded interacting protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 136.6), Kidney (RPKM 119.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (125183311..125970239, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (116305227..117625730, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (124833804..125645895, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D8Sunn9 (e-PCR)
- UniSTS:518656

d8rat117 (e-PCR)
- UniSTS:122400

AW531036 (e-PCR)
- UniSTS:245067

BF404019 (e-PCR)
- UniSTS:246865

D8Got188 (e-PCR)
- UniSTS:113775

D8Rat199 (e-PCR)
- UniSTS:228266

d8mit11 (e-PCR)
- UniSTS:120532

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mRNA 3'-UTR AU-rich region binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables poly(A) binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) binding	ISO Inferred from Sequence Orthology more info
enables poly(U) RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(U) RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in defense response to tumor cell	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of translation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RNA-binding motif, single-stranded-interacting protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401889.1 → NP_001388818.1 RNA-binding motif, single-stranded-interacting protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I6GDD6

Related

ENSRNOP00000039967.7, ENSRNOT00000041548.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

125183311..125970239 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017596208.3 → XP_017451697.3 RNA-binding motif, single-stranded-interacting protein 3 isoform X10
XM_017596203.3 → XP_017451692.3 RNA-binding motif, single-stranded-interacting protein 3 isoform X5

Related

ENSRNOP00000029127.7, ENSRNOT00000036672.8
XM_039082840.2 → XP_038938768.2 RNA-binding motif, single-stranded-interacting protein 3 isoform X7
XM_017596202.3 → XP_017451691.3 RNA-binding motif, single-stranded-interacting protein 3 isoform X4
XM_017596201.3 → XP_017451690.3 RNA-binding motif, single-stranded-interacting protein 3 isoform X3
XM_017596199.3 → XP_017451688.3 RNA-binding motif, single-stranded-interacting protein 3 isoform X1

Related

ENSRNOP00000094964.2, ENSRNOT00000117887.2
XM_063266128.1 → XP_063122198.1 RNA-binding motif, single-stranded-interacting protein 3 isoform X20
XM_063266125.1 → XP_063122195.1 RNA-binding motif, single-stranded-interacting protein 3 isoform X16
XM_063266124.1 → XP_063122194.1 RNA-binding motif, single-stranded-interacting protein 3 isoform X15
XM_063266122.1 → XP_063122192.1 RNA-binding motif, single-stranded-interacting protein 3 isoform X8
XM_063266126.1 → XP_063122196.1 RNA-binding motif, single-stranded-interacting protein 3 isoform X17
XM_039082842.2 → XP_038938770.1 RNA-binding motif, single-stranded-interacting protein 3 isoform X11

UniProtKB/TrEMBL

A6I3S8

Related

ENSRNOP00000085414.2, ENSRNOT00000098379.2

Conserved Domains (2) summary

cd12475
Location:134 → 221

RRM2_RBMS3; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)

cd12472
Location:52 → 131

RRM1_RBMS3; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
XM_001061329.8 → XP_001061329.2 RNA-binding motif, single-stranded-interacting protein 3 isoform X9

UniProtKB/TrEMBL

A0A8I5ZJM8, A6I3S9, A6I3T0

Related

ENSRNOP00000077991.1, ENSRNOT00000094447.2

Conserved Domains (2) summary

cd12475
Location:134 → 221

RRM2_RBMS3; RNA recognition motif 2 found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)

cl17169
Location:51 → 134

RRM_SF; RNA recognition motif (RRM) superfamily
XM_063266127.1 → XP_063122197.1 RNA-binding motif, single-stranded-interacting protein 3 isoform X19
XM_017596207.3 → XP_017451696.1 RNA-binding motif, single-stranded-interacting protein 3 isoform X12

UniProtKB/TrEMBL

A0A8I5ZMK2, A6I3T0

Related

ENSRNOP00000079325.1, ENSRNOT00000095366.2
XM_039082844.2 → XP_038938772.1 RNA-binding motif, single-stranded-interacting protein 3 isoform X14

UniProtKB/TrEMBL

A6I3T0

Conserved Domains (2) summary

cd12475
Location:112 → 199

RRM2_RBMS3; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)

cd12472
Location:30 → 109

RRM1_RBMS3; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
XM_063266123.1 → XP_063122193.1 RNA-binding motif, single-stranded-interacting protein 3 isoform X14

Related

ENSRNOP00000041726.7, ENSRNOT00000039904.8
XM_039082845.2 → XP_038938773.1 RNA-binding motif, single-stranded-interacting protein 3 isoform X18

UniProtKB/TrEMBL

A6I3T0

Conserved Domains (2) summary

cd12475
Location:100 → 187

RRM2_RBMS3; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)

cd12472
Location:18 → 97

RRM1_RBMS3; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
XM_039082846.2 → XP_038938774.1 RNA-binding motif, single-stranded-interacting protein 3 isoform X21

Conserved Domains (2) summary

TIGR01628
Location:3 → 182

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12475
Location:9 → 96

RRM2_RBMS3; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
XM_039082847.2 → XP_038938775.1 RNA-binding motif, single-stranded-interacting protein 3 isoform X22

Conserved Domains (2) summary

TIGR01628
Location:2 → 162

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cl17169
Location:1 → 76

RRM_SF; RNA recognition motif (RRM) superfamily
XM_063266129.1 → XP_063122199.1 RNA-binding motif, single-stranded-interacting protein 3 isoform X22
XM_017596206.3 → XP_017451695.3 RNA-binding motif, single-stranded-interacting protein 3 isoform X6
XM_017596200.3 → XP_017451689.3 RNA-binding motif, single-stranded-interacting protein 3 isoform X2
XM_006244039.5 → XP_006244101.1 RNA-binding motif, single-stranded-interacting protein 3 isoform X13

UniProtKB/TrEMBL

A6I3S8

Conserved Domains (2) summary

cd12475
Location:134 → 221

RRM2_RBMS3; RNA recognition motif 2 found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)

cl17169
Location:51 → 134

RRM_SF; RNA recognition motif (RRM) superfamily