Npl N-acetylneuraminate pyruvate lyase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nplprovided by RGD
Official Full Name: N-acetylneuraminate pyruvate lyaseprovided by RGD
Primary source: RGD:1549702
See related: EnsemblRapid:ENSRNOG00000002775 AllianceGenome:RGD:1549702
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable N-acetylneuraminate lyase activity and identical protein binding activity. Predicted to be involved in N-acetylneuraminate catabolic process. Predicted to be located in cytoplasm. Orthologous to human NPL (N-acetylneuraminate pyruvate lyase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 93.0), Spleen (RPKM 66.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q21

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (68205602..68247940, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (65655099..65697464, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (70938073..70981179, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acetylneuraminate lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetylneuraminate lyase activity	ISO Inferred from Sequence Orthology more info
enables N-acetylneuraminate lyase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables oxo-acid-lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-acetylneuraminate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-acetylneuraminate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in N-acetylneuraminate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in N-acetylneuraminate catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: N-acetylneuraminate lyase

Names: N-acetylneuraminic acid aldolase; NALase; sialate lyase; sialate-pyruvate lyase; sialic acid aldolase; sialic acid lyase

NP_001014006.1

EC 4.1.3.3

XP_006250059.1

EC 4.1.3.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013984.1 → NP_001014006.1 N-acetylneuraminate lyase

See identical proteins and their annotated locations for NP_001014006.1

Status: PROVISIONAL

Source sequence(s)

BC082004

UniProtKB/Swiss-Prot

Q66H59

UniProtKB/TrEMBL

A0A8L2Q119

Related

ENSRNOP00000097337.2, ENSRNOT00000109291.2

Conserved Domains (1) summary

cl21457
Location:8 → 306

TIM; TIM-like beta/alpha barrel domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

68205602..68247940 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249997.5 → XP_006250059.1 N-acetylneuraminate lyase isoform X1

UniProtKB/TrEMBL

A0A8L2Q119

Related

ENSRNOP00000109780.1, ENSRNOT00000167584.1

Conserved Domains (1) summary

cl21457
Location:8 → 275

TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...