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    Tbp TATA box binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117526, updated on 3-Dec-2024

    Summary

    Official Symbol
    Tbpprovided by RGD
    Official Full Name
    TATA box binding proteinprovided by RGD
    Primary source
    RGD:67398
    See related
    EnsemblRapid:ENSRNOG00000001489 AllianceGenome:RGD:67398
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    TFIID
    Summary
    Enables DNA binding activity. Contributes to RNA polymerase II general transcription initiation factor activity. Involved in positive regulation of DNA-templated transcription and spermatogenesis. Part of transcription factor TFIID complex. Human ortholog(s) of this gene implicated in late onset Parkinson's disease; schizophrenia; spinocerebellar ataxia type 17; and type 1 diabetes mellitus. Orthologous to human TBP (TATA-box binding protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 109.4), Thymus (RPKM 73.0) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tbp in Genome Data Viewer
    Location:
    1q12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (65136420..65153515)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (56463330..56480430)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (57491381..57509335)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 120 member B Neighboring gene delta like canonical Notch ligand 1 Neighboring gene uncharacterized LOC102557016 Neighboring gene proteasome 20S subunit beta 1 Neighboring gene programmed cell death 2 Neighboring gene BRCA1 associated RING domain 1, pseudogene 1 Neighboring gene PR/SET domain 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC93994

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase I core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to RNA polymerase II general transcription initiation factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II general transcription initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase III general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables TFIIB-class transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables aryl hydrocarbon receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of RNA polymerase transcription factor SL1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in euchromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in female germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in female pronucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in male pronucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in pronucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription factor TFIIA complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004198.1NP_001004198.1  TATA-box-binding protein

      See identical proteins and their annotated locations for NP_001004198.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081939
      UniProtKB/TrEMBL
      A0A8I5Y1F6, F7FBK7, Q66HB1
      Related
      ENSRNOP00000080115.2, ENSRNOT00000114159.2
      Conserved Domains (2) summary
      PLN00062
      Location:141317
      PLN00062; TATA-box-binding protein; Provisional
      cd04516
      Location:141314
      TBP_eukaryotes; eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      65136420..65153515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006227980.5XP_006228042.1  TATA-box-binding protein isoform X2

      See identical proteins and their annotated locations for XP_006228042.1

      UniProtKB/TrEMBL
      A0A8I5Y1F6, F7FBK7, Q66HB1
      Related
      ENSRNOP00000002038.3, ENSRNOT00000002038.6
      Conserved Domains (2) summary
      PLN00062
      Location:141317
      PLN00062; TATA-box-binding protein; Provisional
      cd04516
      Location:141314
      TBP_eukaryotes; eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation ...
    2. XM_063268389.1XP_063124459.1  TATA-box-binding protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y1F6