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    Cdc123 cell division cycle 123 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116656, updated on 3-Dec-2024

    Summary

    Official Symbol
    Cdc123provided by RGD
    Official Full Name
    cell division cycle 123provided by RGD
    Primary source
    RGD:619766
    See related
    EnsemblRapid:ENSRNOG00000017770 AllianceGenome:RGD:619766
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    D123
    Summary
    Predicted to enable ATP binding activity; magnesium ion binding activity; and protein folding chaperone. Predicted to be involved in eukaryotic translation initiation factor 2 complex assembly. Predicted to be active in cytoplasm. Orthologous to human CDC123 (cell division cycle 123). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 290.2), Brain (RPKM 278.5) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cdc123 in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (77368376..77412659)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (72459270..72503316)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (76410629..76454275)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene dehydrogenase E1 and transketolase domain containing 1 Neighboring gene large ribosomal subunit protein eL37-like Neighboring gene SEC61 translocon subunit alpha 2 Neighboring gene nudix hydrolase 5 Neighboring gene uncharacterized LOC102551026 Neighboring gene uncharacterized LOC102551092

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein folding chaperone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in eukaryotic translation initiation factor 2 complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in eukaryotic translation initiation factor 2 complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    translation initiation factor eIF2 assembly protein
    Names
    D123 gene product
    cell division cycle 123 homolog
    cell division cycle protein 123 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053877.4NP_446329.1  translation initiation factor eIF2 assembly protein

      See identical proteins and their annotated locations for NP_446329.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      Q62834
      UniProtKB/TrEMBL
      A0A8I5ZX90, A6JLY4
      Related
      ENSRNOP00000089218.2, ENSRNOT00000117639.2
      Conserved Domains (1) summary
      pfam07065
      Location:14314
      D123; D123

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      77368376..77412659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276027.1XP_063132097.1  translation initiation factor eIF2 assembly protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZX90