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    Lilra5 leukocyte immunoglobulin like receptor A5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691533, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lilra5provided by RGD
    Official Full Name
    leukocyte immunoglobulin like receptor A5provided by RGD
    Primary source
    RGD:1582781
    See related
    EnsemblRapid:ENSRNOG00000027808 AllianceGenome:RGD:1582781
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lilrc1
    Summary
    Predicted to enable inhibitory MHC class I receptor activity. Predicted to be involved in several processes, including positive regulation of MAPK cascade; positive regulation of protein tyrosine kinase activity; and regulation of cytokine production. Predicted to be located in cell surface and extracellular space. Predicted to be active in plasma membrane. Orthologous to human LILRA5 (leukocyte immunoglobulin like receptor A5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 160.9), Liver (RPKM 62.0) and 7 other tissues See more
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    Genomic context

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    See Lilra5 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (79011865..79073860, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (69973292..69978750, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (73655767..73682232, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin like receptor B4, pseudogene 1 Neighboring gene leukocyte immunoglobulin like receptor B3 Neighboring gene ornithine decarboxylase 1, pseudogene 7 Neighboring gene CDC42 effector protein 5 Neighboring gene leukocyte receptor cluster member 9 Neighboring gene leukocyte receptor cluster member 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. LILRA5 is expressed by synovial tissue macrophages in rheumatoid arthritis, selectively induces pro-inflammatory cytokines and IL-10 and is regulated by TNF-alpha, IL-10 and IFN-gamma. Mitchell A, et al. Eur J Immunol, 2008 Dec. PMID 19009525
    2. LIR9, an immunoglobulin-superfamily-activating receptor, is expressed as a transmembrane and as a secreted molecule. Borges L, et al. Blood, 2003 Feb 15. PMID 12393390
    3. Molecular cloning of LILRC1 and LILRC2 in the mouse and the rat, two novel immunoglobulin-like receptors encoded by the leukocyte receptor gene complex. Hoelsbrekken SE, et al. Immunogenetics, 2005 Aug. PMID 16041585
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LILRC1 and LILRC2 both have two extracellular Ig-like domains and a cytoplasmic tail devoid of any known signaling motifs. The transmembrane regions contain an arginine residue.
      Title: Molecular cloning of LILRC1 and LILRC2 in the mouse and the rat, two novel immunoglobulin-like receptors encoded by the leukocyte receptor gene complex.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables inhibitory MHC class I receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response-regulating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of interleukin-12 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-13 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leukocyte immunoglobulin-like receptor subfamily A member 5
    Names
    leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076793.3 → NP_001070261.1  leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001070261.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      D4A6Y0
      Related
      ENSRNOP00000035173.6, ENSRNOT00000038802.7
      Conserved Domains (1) summary
      cl11960
      Location:123 → 219
      Ig; Immunoglobulin domain

    2. NM_001430272.1 → NP_001417201.1  leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6A5R5

    3. NM_001430273.1 → NP_001417202.1  leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    4. NM_001430274.1 → NP_001417203.1  leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      79011865..79073860 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274900.1 → XP_063130970.1  leukocyte immunoglobulin-like receptor subfamily A member 5 isoform X6

    2. XM_063274891.1 → XP_063130961.1  leukocyte immunoglobulin-like receptor subfamily A member 5 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTC1

    3. XM_063274892.1 → XP_063130962.1  leukocyte immunoglobulin-like receptor subfamily A member 5 isoform X2

    4. XM_063274896.1 → XP_063130966.1  leukocyte immunoglobulin-like receptor subfamily A member 5 isoform X4

    5. XM_008758988.4 → XP_008757210.1  leukocyte immunoglobulin-like receptor subfamily A member 5 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTC1, D4A6Y0
      Conserved Domains (1) summary
      cl11960
      Location:125 → 221
      Ig; Immunoglobulin domain

    6. XM_063274901.1 → XP_063130971.1  leukocyte immunoglobulin-like receptor subfamily A member 5 isoform X7

    7. XM_006228225.5 → XP_006228287.1  leukocyte immunoglobulin-like receptor subfamily A member 5 isoform X3

      Conserved Domains (1) summary
      cl11960
      Location:111 → 207
      Ig; Immunoglobulin domain

    8. XM_063274899.1 → XP_063130969.1  leukocyte immunoglobulin-like receptor subfamily A member 5 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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