U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Slc16a1 solute carrier family 16 member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25027, updated on 3-Dec-2024

    Summary

    Official Symbol
    Slc16a1provided by RGD
    Official Full Name
    solute carrier family 16 member 1provided by RGD
    Primary source
    RGD:3690
    See related
    EnsemblRapid:ENSRNOG00000019996 AllianceGenome:RGD:3690
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MCT1; RNMCT1; RATMCT1
    Summary
    Enables identical protein binding activity; lactate:proton symporter activity; and organic cyclic compound binding activity. Involved in cellular response to organic cyclic compound; plasma membrane lactate transport; and pyruvate transmembrane transport. Located in apical plasma membrane and basolateral plasma membrane. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 7. Orthologous to human SLC16A1 (solute carrier family 16 member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 1100.1), Thymus (RPKM 589.2) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Slc16a1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (194805556..194832966)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (192123755..192144617)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (207108552..207129352)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA leucine (anticodon AAG) 9 Neighboring gene uncharacterized LOC102547750 Neighboring gene RNA, U6 small nuclear 406

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carboxylic acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lactate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lactate:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lactate:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lactate:proton symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables monocarboxylic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables monocarboxylic acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables organic cyclic compound binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables organic cyclic compound binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables solute:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables succinate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables succinate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in behavioral response to nutrient ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in carboxylic acid transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to organic cyclic compound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lactate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lactate transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monocarboxylic acid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in monocarboxylic acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in plasma membrane lactate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in plasma membrane lactate transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in plasma membrane lactate transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in plasma membrane lactate transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pyruvate catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyruvate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to food ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in succinate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in succinate transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    monocarboxylate transporter 1
    Names
    MCT 1
    solute carrier 16 (monocarboxylic acid transporter), member 1
    solute carrier family 16 (monocarboxylate transporter), member 1
    solute carrier family 16 (monocarboxylic acid transporters), member 1
    solute carrier family 16, member 1 (monocarboxylic acid transporter 1)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012716.2NP_036848.1  monocarboxylate transporter 1

      See identical proteins and their annotated locations for NP_036848.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078877
      UniProtKB/Swiss-Prot
      P53987
      UniProtKB/TrEMBL
      A0A8I6AI36, A6K3P1
      Related
      ENSRNOP00000027234.3, ENSRNOT00000027234.7
      Conserved Domains (1) summary
      TIGR00892
      Location:1462
      2A0113; monocarboxylate transporter 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      194805556..194832966
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101760.2XP_038957688.1  monocarboxylate transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      P53987
      UniProtKB/TrEMBL
      A0A8I6AI36, A6K3P1
      Conserved Domains (1) summary
      TIGR00892
      Location:1462
      2A0113; monocarboxylate transporter 1
    2. XM_063281316.1XP_063137386.1  monocarboxylate transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      P53987
      UniProtKB/TrEMBL
      A0A8I6AI36, A6K3P1
      Related
      ENSRNOP00000092404.1, ENSRNOT00000116493.2