Drp2 dystrophin related protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Drp2provided by RGD
Official Full Name: dystrophin related protein 2provided by RGD
Primary source: RGD:621750
See related: EnsemblRapid:ENSRNOG00000026704 AllianceGenome:RGD:621750
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DRP-2
Summary: Predicted to enable zinc ion binding activity. Involved in synapse organization. Located in dendrite. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human DRP2 (dystrophin related protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 70.7), Adrenal (RPKM 36.7) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq32

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (101900743..101951403)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (97607577..97658117)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (105239623..105290233)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DRP-2 is a potential marker for escitalopram resistance in an animal model of stress and depression.
Title: Proteomic investigation of the ventral rat hippocampus links DRP-2 to escitalopram treatment resistance and SNAP to stress resilience in the chronic mild stress model of depression.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in central nervous system development	IEA Inferred from Electronic Annotation more info
involved_in synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dystrophin-related protein 2

Names: dystrophin-related protein 2 A-form

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395076.1 → NP_001382005.1 dystrophin-related protein 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

G3V971, Q9EPA0

UniProtKB/TrEMBL

A0A8L2R2Z3

Conserved Domains (4) summary

cd00176
Location:111 → 339

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:357 → 385

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:608 → 656

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16248
Location:422 → 583

EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)
NM_023971.2 → NP_076461.2 dystrophin-related protein 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

G3V971, Q9EPA0

UniProtKB/TrEMBL

A0A8L2R2Z3

Related

ENSRNOP00000037371.3, ENSRNOT00000039864.5

Conserved Domains (4) summary

cd00176
Location:111 → 339

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:357 → 385

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:608 → 656

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16248
Location:422 → 583

EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

101900743..101951403

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008773433.4 → XP_008771655.1 dystrophin-related protein 2 isoform X1

See identical proteins and their annotated locations for XP_008771655.1

UniProtKB/Swiss-Prot

G3V971, Q9EPA0

UniProtKB/TrEMBL

A0A8L2R2Z3

Conserved Domains (4) summary

cd00176
Location:111 → 339

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:357 → 385

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:608 → 656

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

cd16248
Location:422 → 583

EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)
XM_063280292.1 → XP_063136362.1 dystrophin-related protein 2 isoform X2

Related

ENSRNOP00000070220.3, ENSRNOT00000085693.3
XM_063280291.1 → XP_063136361.1 dystrophin-related protein 2 isoform X1

UniProtKB/Swiss-Prot

G3V971, Q9EPA0
XM_008773436.4 → XP_008771658.1 dystrophin-related protein 2 isoform X3

UniProtKB/TrEMBL

A0A8L2R2Z3

Conserved Domains (5) summary

cd00176
Location:33 → 261

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:279 → 307

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:530 → 578

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam09068
Location:308 → 426

EF-hand_2; EF hand

pfam09069
Location:430 → 521

EF-hand_3; EF-hand