Senp2 SUMO specific peptidase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Senp2provided by RGD
Official Full Name: SUMO specific peptidase 2provided by RGD
Primary source: RGD:708378
See related: EnsemblRapid:ENSRNOG00000001773 AllianceGenome:RGD:708378
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Axam
Summary: Enables protein domain specific binding activity. Involved in dorsal/ventral axis specification and positive regulation of protein phosphorylation. Predicted to be located in PML body and cytosol. Predicted to be part of nuclear pore. Predicted to be active in nucleus. Orthologous to human SENP2 (SUMO specific peptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 123.2), Spleen (RPKM 75.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (92487259..92522795, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (78981429..79018274, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (82627973..82664702, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of Serotonin 1A Receptor SUMOylation by SENP2 and PIASxalpha.
Title: Regulation of Serotonin 1A Receptor SUMOylation by SENP2 and PIASxα.
Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.
Title: Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.
Data suggest that SENP2 in hepatic stellate cells is involved in regulation of apoptosis in these cells and in development/reversion of liver fibrosis (here, carbon tetrachloride-induced liver fibrosis).
Title: SENP2 alleviates CCl(4)-induced liver fibrosis by promoting activated hepatic stellate cell apoptosis and reversion.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW554757 (e-PCR)
- UniSTS:186065

RH141486 (e-PCR)
- UniSTS:223480

RH129168 (e-PCR)
- UniSTS:212476

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SUMO-specific endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables SUMO-specific endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables deSUMOylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deSUMOylase activity	IEA Inferred from Electronic Annotation more info
enables deSUMOylase activity	ISO Inferred from Sequence Orthology more info
enables deSUMOylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in dorsal/ventral axis specification	IDA Inferred from Direct Assay more info	PubMed
involved_in fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in labyrinthine layer development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within labyrinthine layer development	ISO Inferred from Sequence Orthology more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in protein desumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein desumoylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein desumoylation	ISO Inferred from Sequence Orthology more info
involved_in protein desumoylation	ISO Inferred from Sequence Orthology more info
involved_in protein desumoylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA endoreduplication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA endoreduplication	ISO Inferred from Sequence Orthology more info
involved_in regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in spongiotrophoblast layer development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spongiotrophoblast layer development	ISO Inferred from Sequence Orthology more info
involved_in trophoblast giant cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within trophoblast giant cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in PML body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sentrin-specific protease 2

Names: Axin-associating molecule; SUMO/sentrin specific peptidase 2; SUMO/sentrin specific protease 2; Sumo1/sentrin/SMT3 specific peptidase 2; sentrin/SUMO-specific protease SENP2

NP_076479.1

EC 3.4.22.68

XP_008767027.1

EC 3.4.22.68

XP_038944560.1

EC 3.4.22.68

XP_063126841.1

EC 3.4.22.68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023989.1 → NP_076479.1 sentrin-specific protease 2

See identical proteins and their annotated locations for NP_076479.1

Status: PROVISIONAL

Source sequence(s)

AF260129

UniProtKB/Swiss-Prot

Q9EQE1

UniProtKB/TrEMBL

A0A8I5ZTE8, A6JS62

Conserved Domains (1) summary

cl23802
Location:337 → 583

Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

92487259..92522795 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008768805.4 → XP_008767027.1 sentrin-specific protease 2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZTE8, A0A8L2PZM6

Related

ENSRNOP00000002425.5, ENSRNOT00000002425.8

Conserved Domains (1) summary

cl23802
Location:372 → 588

Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
XM_063270771.1 → XP_063126841.1 sentrin-specific protease 2 isoform X3

UniProtKB/TrEMBL

A0A0G2K009, A0A8I5ZTE8

Related

ENSRNOP00000071258.2, ENSRNOT00000087105.3
XM_039088632.2 → XP_038944560.1 sentrin-specific protease 2 isoform X2

UniProtKB/TrEMBL

A0A8I5ZTE8

Conserved Domains (1) summary

COG5160
Location:379 → 584

ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]