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    Epc2 enhancer of polycomb homolog 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362132, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Epc2provided by RGD
    Official Full Name
    enhancer of polycomb homolog 2provided by RGD
    Primary source
    RGD:1307271
    See related
    EnsemblRapid:ENSRNOG00000029447 AllianceGenome:RGD:1307271
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in positive regulation of double-strand break repair via homologous recombination; regulation of cell cycle; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of NuA4 histone acetyltransferase complex; nucleosome; and piccolo histone acetyltransferase complex. Orthologous to human EPC2 (enhancer of polycomb homolog 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 140.2), Lung (RPKM 108.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Epc2 in Genome Data Viewer
    Location:
    3q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (54276187..54376373)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (33867219..33967908)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (33641616..33741219)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene origin recognition complex, subunit 4 Neighboring gene methyl-CpG binding domain protein 5 Neighboring gene uncharacterized LOC120101434 Neighboring gene kinesin family member 5C Neighboring gene uncharacterized LOC102556679 Neighboring gene Ly6/Plaur domain containing 6B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Watanabe S, et al. Cold Spring Harb Symp Quant Biol, 2010. PMID 21502417
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of piccolo histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    enhancer of polycomb homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108581.1 → NP_001102051.1  enhancer of polycomb homolog 2

      See identical proteins and their annotated locations for NP_001102051.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473983
      UniProtKB/TrEMBL
      A6JEZ5, D4ADG5
      Related
      ENSRNOP00000040649.3, ENSRNOT00000051953.5
      Conserved Domains (2) summary
      pfam06752
      Location:578 → 808
      E_Pc_C; Enhancer of Polycomb C-terminus
      pfam10513
      Location:7 → 148
      EPL1; Enhancer of polycomb-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      54276187..54376373
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284106.1 → XP_063140176.1  enhancer of polycomb homolog 2 isoform X1

    2. XM_063284107.1 → XP_063140177.1  enhancer of polycomb homolog 2 isoform X2

    3. XM_006234155.5 → XP_006234217.1  enhancer of polycomb homolog 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZZ28
      Related
      ENSRNOP00000083318.1, ENSRNOT00000115060.2
      Conserved Domains (2) summary
      pfam06752
      Location:514 → 744
      E_Pc_C; Enhancer of Polycomb C-terminus
      pfam10513
      Location:7 → 148
      EPL1; Enhancer of polycomb-like
    Nucleotide Protein Strain
    Heading Accession and Version

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