Aldh1l2 aldehyde dehydrogenase 1 family, member L2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aldh1l2provided by RGD
Official Full Name: aldehyde dehydrogenase 1 family, member L2provided by RGD
Primary source: RGD:1309458
See related: EnsemblRapid:ENSRNOG00000008586 AllianceGenome:RGD:1309458
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309458
Summary: Predicted to enable aldehyde dehydrogenase (NAD+) activity and formyltetrahydrofolate dehydrogenase activity. Predicted to be involved in 10-formyltetrahydrofolate catabolic process; NADPH regeneration; and folic acid metabolic process. Predicted to act upstream of or within with a positive effect on fatty acid beta-oxidation. Predicted to be located in mitochondrion and nucleoplasm. Orthologous to human ALDH1L2 (aldehyde dehydrogenase 1 family member L2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 337.1), Muscle (RPKM 25.0) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q13

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (22141872..22193403)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (20254246..20305793)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (26375866..26425838)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU049799 (e-PCR)
- UniSTS:146245

RH130819 (e-PCR)
- UniSTS:214103

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aldehyde dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables formyltetrahydrofolate dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables formyltetrahydrofolate dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 10-formyltetrahydrofolate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in NADPH regeneration	ISO Inferred from Sequence Orthology more info
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_positive_effect fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in folic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in one-carbon metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial 10-formyltetrahydrofolate dehydrogenase

Names: probable 10-formyltetrahydrofolate dehydrogenase ALDH1L2

NP_001178707.2

EC 1.5.1.6

NP_001401850.1

EC 1.5.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191778.3 → NP_001178707.2 mitochondrial 10-formyltetrahydrofolate dehydrogenase isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I5ZJL8

Related

ENSRNOP00000103361.1, ENSRNOT00000167569.1

Conserved Domains (4) summary

cd07140
Location:438 → 923

ALDH_F1L_FTFDH; 10-formyltetrahydrofolate dehydrogenase, ALDH family 1L

cd08647
Location:23 → 225

FMT_core_FDH_N; 10-formyltetrahydrofolate dehydrogenase (FDH), N-terminal hydrolase domain

cd08703
Location:228 → 327

FDH_Hydrolase_C; The C-terminal subdomain of the hydrolase domain on the bi-functional protein 10-formyltetrahydrofolate dehydrogenase

pfam00550
Location:346 → 390

PP-binding; Phosphopantetheine attachment site
NM_001414921.1 → NP_001401850.1 mitochondrial 10-formyltetrahydrofolate dehydrogenase isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I5ZRH3

Related

ENSRNOP00000080990.1, ENSRNOT00000118245.2