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    Ifnar1 interferon alpha and beta receptor subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288264, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ifnar1provided by RGD
    Official Full Name
    interferon alpha and beta receptor subunit 1provided by RGD
    Primary source
    RGD:1305399
    See related
    EnsemblRapid:ENSRNOG00000028594 AllianceGenome:RGD:1305399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable JAK pathway signal transduction adaptor activity; type I interferon binding activity; and type I interferon receptor activity. Involved in cytokine-mediated signaling pathway. Predicted to be located in endosome and lysosome. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hepatitis C and primary immunodeficiency disease. Orthologous to human IFNAR1 (interferon alpha and beta receptor subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 331.9), Spleen (RPKM 237.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ifnar1 in Genome Data Viewer
    Location:
    11q11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (44211769..44238206)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (30725774..30752227)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (31640407..31666839)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095617 Neighboring gene uncharacterized LOC120095616 Neighboring gene uncharacterized LOC102554317 Neighboring gene small ribosomal subunit protein eS7-like Neighboring gene uncharacterized LOC134481058 Neighboring gene interferon gamma receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Staphylococcus aureus activates type I IFN signaling in mice and humans through the Xr repeated sequences of protein A. Martin FJ, et al. J Clin Invest, 2009 Jul. PMID 19603548, Free PMC Article
    2. A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats. Qaisar N, et al. Diabetes, 2017 Jan. PMID 27999109, Free PMC Article
    3. Regional and temporal expression patterns of interleukin-10, interleukin-10 receptor and adhesion molecules in the rat spinal cord during chronic relapsing EAE. Ledeboer A, et al. J Neuroimmunol, 2003 Mar. PMID 12620647
    4. Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice. Shahangian A, et al. J Clin Invest, 2009 Jul. PMID 19487810, Free PMC Article
    5. Type I interferon signaling regulates Ly6C(hi) monocytes and neutrophils during acute viral pneumonia in mice. Seo SU, et al. PLoS Pathog, 2011 Feb. PMID 21383977, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables JAK pathway signal transduction adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cytokine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interferon receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables type I interferon binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables type I interferon receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables type I interferon receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell surface receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interferon-alpha ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cellular respiration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in type I interferon-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interferon alpha/beta receptor 1
    Names
    interferon (alpha and beta) receptor 1
    interferon (alpha, beta and omega) receptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105893.1 → NP_001099363.2  interferon alpha/beta receptor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001099363.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6JLF6, D3ZDS9
      Conserved Domains (2) summary
      pfam09294
      Location:126 → 223
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
      cl21522
      Location:29 → 114
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. NM_001271316.1 → NP_001258245.1  interferon alpha/beta receptor 1 isoform 2

      See identical proteins and their annotated locations for NP_001258245.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an additional exon, compared to variant 1. This difference causes translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A0G2JXD8, A6JLF8
      Conserved Domains (1) summary
      cl21522
      Location:175 → 271
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      44211769..44238206
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270427.1 → XP_063126497.1  interferon alpha/beta receptor 1 isoform X1

      Related
      ENSRNOP00000031611.6, ENSRNOT00000029985.8

    2. XM_063270428.1 → XP_063126498.1  interferon alpha/beta receptor 1 isoform X3

    3. XM_039088212.2 → XP_038944140.1  interferon alpha/beta receptor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AH72
      Related
      ENSRNOP00000070232.2, ENSRNOT00000091472.3
      Conserved Domains (2) summary
      pfam09294
      Location:115 → 212
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
      cl21522
      Location:18 → 103
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    4. XM_017597942.2 → XP_017453431.1  interferon alpha/beta receptor 1 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JXD8, A6JLF8
      Conserved Domains (1) summary
      cl21522
      Location:175 → 271
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    5. XM_063270429.1 → XP_063126499.1  interferon alpha/beta receptor 1 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JXD8, A6JLF8
    Nucleotide Protein Strain
    Heading Accession and Version

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