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    Gemin5 gem (nuclear organelle) associated protein 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691231, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gemin5provided by RGD
    Official Full Name
    gem (nuclear organelle) associated protein 5provided by RGD
    Primary source
    RGD:1586275
    See related
    EnsemblRapid:ENSRNOG00000002645 AllianceGenome:RGD:1586275
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity and ribosome binding activity. Predicted to be involved in regulation of translation and spliceosomal snRNP assembly. Predicted to be located in cytosol and nuclear body. Predicted to be part of SMN complex and SMN-Gemin2 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with cerebellar atrophy and motor dysfunction. Orthologous to human GEMIN5 (gem nuclear organelle associated protein 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 82.5), Spleen (RPKM 70.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gemin5 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (42797975..42843356, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (42295729..42342902, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (43552260..43599241, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480692 Neighboring gene transfer RNA serine (anticodon AGA) 43 Neighboring gene CCR4-NOT transcription complex, subunit 8 Neighboring gene mitochondrial ribosomal protein L22 Neighboring gene interferon gamma induced GTPase like 1 Neighboring gene uncharacterized LOC134480693

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5. Jin W, et al. Genes Dev, 2016 Nov 1. PMID 27881601, Free PMC Article
    2. Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly. Xu C, et al. Genes Dev, 2016 Nov 1. PMID 27881600, Free PMC Article
    3. The RNA-binding protein Gemin5 binds directly to the ribosome and regulates global translation. Francisco-Velilla R, et al. Nucleic Acids Res, 2016 Sep 30. PMID 27507887, Free PMC Article
    4. Gemin5-snRNA interaction reveals an RNA binding function for WD repeat domains. Lau CK, et al. Nat Struct Mol Biol, 2009 May. PMID 19377484
    5. The Gemin5 protein of the SMN complex identifies snRNAs. Battle DJ, et al. Mol Cell, 2006 Jul 21. PMID 16857593

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables U1 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables U4 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables U4atac snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal snRNP assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SMN complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SMN complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SMN-Gemin2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SMN-Sm protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    gem-associated protein 5
    Names
    rCG34955-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172089.1 → NP_001165560.1  gem-associated protein 5

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D3ZGD0
      Conserved Domains (4) summary
      COG2319
      Location:287 → 710
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:154 → 193
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:57 → 408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl12013
      Location:1338 → 1444
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      42797975..42843356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246400.4 → XP_006246462.1  gem-associated protein 5 isoform X6

      Conserved Domains (4) summary
      COG2319
      Location:53 → 410
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:154 → 193
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:57 → 407
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl12013
      Location:1336 → 1443
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_006246399.4 → XP_006246461.1  gem-associated protein 5 isoform X5

      Conserved Domains (4) summary
      COG2319
      Location:53 → 410
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:154 → 193
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:57 → 407
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl12013
      Location:1337 → 1443
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. XM_006246398.4 → XP_006246460.1  gem-associated protein 5 isoform X3

      Conserved Domains (4) summary
      COG2319
      Location:53 → 410
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:154 → 193
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:57 → 407
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl12013
      Location:1337 → 1444
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    4. XM_039086891.2 → XP_038942819.1  gem-associated protein 5 isoform X4

      UniProtKB/TrEMBL
      A6HER3
      Conserved Domains (3) summary
      COG2319
      Location:287 → 710
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:154 → 193
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:57 → 408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. XM_006246397.4 → XP_006246459.1  gem-associated protein 5 isoform X2

      Conserved Domains (4) summary
      COG2319
      Location:287 → 710
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:154 → 193
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:57 → 408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl12013
      Location:1337 → 1444
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    6. XM_006246396.4 → XP_006246458.1  gem-associated protein 5 isoform X1

      UniProtKB/TrEMBL
      D3ZGD0
      Related
      ENSRNOP00000050493.5, ENSRNOT00000044299.7
      Conserved Domains (4) summary
      COG2319
      Location:287 → 710
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:154 → 193
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:57 → 408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl12013
      Location:1338 → 1445
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    7. XM_006246401.5 → XP_006246463.1  gem-associated protein 5 isoform X7

      Conserved Domains (2) summary
      COG2319
      Location:25 → 448
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:69 → 115
      7WD40; WD40 repeat [structural motif]

    8. XM_039086892.2 → XP_038942820.1  gem-associated protein 5 isoform X7

      Conserved Domains (2) summary
      COG2319
      Location:25 → 448
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:69 → 115
      7WD40; WD40 repeat [structural motif]

    9. XM_063269897.1 → XP_063125967.1  gem-associated protein 5 isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version

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