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    Dmrt2 doublesex and mab-3 related transcription factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309430, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dmrt2provided by RGD
    Official Full Name
    doublesex and mab-3 related transcription factor 2provided by RGD
    Primary source
    RGD:1309047
    See related
    EnsemblRapid:ENSRNOG00000016301 AllianceGenome:RGD:1309047
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and sex differentiation. Predicted to act upstream of or within embryonic skeletal system development; positive regulation of myotome development; and regulation of somitogenesis. Predicted to be active in nucleus. Orthologous to human DMRT2 (doublesex and mab-3 related transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 72.1), Thymus (RPKM 55.4) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dmrt2 in Genome Data Viewer
    Location:
    1q51
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (232743935..232750431)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (223317543..223324131)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (243662819..243669312)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene doublesex and mab-3 related transcription factor 1 Neighboring gene doublesex and mab-3 related transcription factor 3 Neighboring gene transfer RNA proline (anticodon AGG) 60 Neighboring gene uncharacterized LOC108349212

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dmrt2 and Pax3 double-knockout mice show severe defects in embryonic myogenesis. Seo KW. Comp Med, 2007 Oct. PMID 17974128
    2. Left-right function of dmrt2 genes is not conserved between zebrafish and mouse. Lourenço R, et al. PLoS One, 2010 Dec 28. PMID 21203428, Free PMC Article
    3. Vertebrate DM domain proteins bind similar DNA sequences and can heterodimerize on DNA. Murphy MW, et al. BMC Mol Biol, 2007 Jul 2. PMID 17605809, Free PMC Article
    4. Targeted disruption of the DM domain containing transcription factor Dmrt2 reveals an essential role in somite patterning. Seo KW, et al. Dev Biol, 2006 Feb 1. PMID 16387292
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryonic skeletal system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT acts_upstream_of_or_within left/right pattern formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of myotome development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of myotome development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of somitogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sex differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    doublesex- and mab-3-related transcription factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107597.1 → NP_001101067.1  doublesex- and mab-3-related transcription factor 2

      See identical proteins and their annotated locations for NP_001101067.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/TrEMBL
      A6I0S3, D4A098
      Related
      ENSRNOP00000059880.2, ENSRNOT00000067372.3
      Conserved Domains (1) summary
      pfam00751
      Location:117 → 163
      DM; DM DNA binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      232743935..232750431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760307.3 → XP_008758529.1  doublesex- and mab-3-related transcription factor 2 isoform X3

      See identical proteins and their annotated locations for XP_008758529.1

      Conserved Domains (1) summary
      pfam00751
      Location:117 → 163
      DM; DM DNA binding domain

    2. XM_039080293.2 → XP_038936221.1  doublesex- and mab-3-related transcription factor 2 isoform X1

      UniProtKB/TrEMBL
      D4A098

    3. XM_063264772.1 → XP_063120842.1  doublesex- and mab-3-related transcription factor 2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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