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    Rbm6 RNA binding motif protein 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315997, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rbm6provided by RGD
    Official Full Name
    RNA binding motif protein 6provided by RGD
    Primary source
    RGD:1560367
    See related
    EnsemblRapid:ENSRNOG00000018333 AllianceGenome:RGD:1560367
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560367
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be active in nucleus. Orthologous to human RBM6 (RNA binding motif protein 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 174.4), Adrenal (RPKM 144.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rbm6 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (117327607..117431397, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (108452687..108552783, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (116535403..116635851, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480231 Neighboring gene G protein subunit alpha transducin 1 Neighboring gene semaphorin 3F Neighboring gene RNA binding motif protein 5 Neighboring gene cofilin 1 like 1 Neighboring gene enolase 1, pseudogene 23 Neighboring gene PCNA-associated factor-like Neighboring gene transfer RNA proline (anticodon AGG) 36

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The novel protein MANI modulates neurogenesis and neurite-cone growth. Mishra M, et al. J Cell Mol Med, 2011 Aug. PMID 20716133, Free PMC Article
    2. Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Sutherland HG, et al. Hum Mol Genet, 2001 Sep 1. PMID 11555636
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108186.1 → NP_001101656.1  RNA-binding protein 6

      See identical proteins and their annotated locations for NP_001101656.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473954
      UniProtKB/TrEMBL
      A0A8I6A326, A6I311, D4ACW0
      Related
      ENSRNOP00000024939.5, ENSRNOT00000024939.7
      Conserved Domains (6) summary
      COG1357
      Location:92 → 251
      YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]
      cd12314
      Location:456 → 533
      RRM1_RBM6; RNA recognition motif 1 in vertebrate RNA-binding protein 6 (RBM6)
      cd12563
      Location:651 → 737
      RRM2_RBM6; RNA recognition motif 2 in vertebrate RNA-binding protein 6 (RBM6)
      pfam01585
      Location:1048 → 1091
      G-patch; G-patch domain
      cd16074
      Location:769 → 776
      OCRE; OCRE repeat 1 [structural motif]
      cl23757
      Location:763 → 818
      OCRE; OCRE domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      117327607..117431397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081594.2 → XP_038937522.1  RNA-binding protein 6 isoform X3

      Conserved Domains (4) summary
      cd16074
      Location:247 → 254
      OCRE; OCRE repeat 1 [structural motif]
      cl23757
      Location:241 → 296
      OCRE; OCRE domain
      pfam01585
      Location:526 → 569
      G-patch; G-patch domain
      cd12563
      Location:129 → 215
      RRM2_RBM6; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 6 (RBM6)

    2. XM_006243780.5 → XP_006243842.1  RNA-binding protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006243842.1

      UniProtKB/TrEMBL
      A0A8I6A326, A6I311, D4ACW0
      Conserved Domains (6) summary
      COG1357
      Location:92 → 251
      YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]
      cd12314
      Location:456 → 533
      RRM1_RBM6; RNA recognition motif 1 in vertebrate RNA-binding protein 6 (RBM6)
      cd12563
      Location:651 → 737
      RRM2_RBM6; RNA recognition motif 2 in vertebrate RNA-binding protein 6 (RBM6)
      pfam01585
      Location:1048 → 1091
      G-patch; G-patch domain
      cd16074
      Location:769 → 776
      OCRE; OCRE repeat 1 [structural motif]
      cl23757
      Location:763 → 818
      OCRE; OCRE domain

    3. XM_063265629.1 → XP_063121699.1  RNA-binding protein 6 isoform X2

    4. XM_063265628.1 → XP_063121698.1  RNA-binding protein 6 isoform X2

    5. XM_006243781.4 → XP_006243843.1  RNA-binding protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006243843.1

      UniProtKB/TrEMBL
      A0A8I6A326, A6I311, D4ACW0
      Conserved Domains (6) summary
      COG1357
      Location:92 → 251
      YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]
      cd12314
      Location:456 → 533
      RRM1_RBM6; RNA recognition motif 1 in vertebrate RNA-binding protein 6 (RBM6)
      cd12563
      Location:651 → 737
      RRM2_RBM6; RNA recognition motif 2 in vertebrate RNA-binding protein 6 (RBM6)
      pfam01585
      Location:1048 → 1091
      G-patch; G-patch domain
      cd16074
      Location:769 → 776
      OCRE; OCRE repeat 1 [structural motif]
      cl23757
      Location:763 → 818
      OCRE; OCRE domain

    6. XM_039081595.2 → XP_038937523.1  RNA-binding protein 6 isoform X3

      Conserved Domains (4) summary
      cd16074
      Location:247 → 254
      OCRE; OCRE repeat 1 [structural motif]
      cl23757
      Location:241 → 296
      OCRE; OCRE domain
      pfam01585
      Location:526 → 569
      G-patch; G-patch domain
      cd12563
      Location:129 → 215
      RRM2_RBM6; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 6 (RBM6)

    7. XM_008766535.4 → XP_008764757.1  RNA-binding protein 6 isoform X3

      Conserved Domains (4) summary
      cd16074
      Location:247 → 254
      OCRE; OCRE repeat 1 [structural motif]
      cl23757
      Location:241 → 296
      OCRE; OCRE domain
      pfam01585
      Location:526 → 569
      G-patch; G-patch domain
      cd12563
      Location:129 → 215
      RRM2_RBM6; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 6 (RBM6)
    Nucleotide Protein Strain
    Heading Accession and Version

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