Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Nucks1provided by RGD
Full Name: nuclear casein kinase and cyclin-dependent kinase substrate 1provided by RGD
Primary source: RGD:620993
See related: EnsemblRapid:ENSRNOG00000047287 AllianceGenome:RGD:620993
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nucks
Summary: Enables single-stranded DNA binding activity. Predicted to be involved in several processes, including DNA metabolic process; cellular response to X-ray; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within glucose homeostasis and positive regulation of insulin receptor signaling pathway. Predicted to be located in chromatin; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human NUCKS1 (nuclear casein kinase and cyclin dependent kinase substrate 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 458.6), Brain (RPKM 444.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (45897275..45926491)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (43345091..43374316)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (48679726..48709663)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that Nucks expression increased during the initial stages of embryonic development, and then gradually decreased until birth in all tissues except the nervous tissue and muscle fibers.
Title: Dynamic expression of the vertebrate-specific protein Nucks during rodent embryonic development.
The expression of Nucks in both proliferating and quiescent cells and its correlation with Bax levels and apoptosis strongly suggest that Nucks plays complex roles in cell homeostasis.
Title: Dynamic expression of the vertebrate-specific protein Nucks during rodent embryonic development.
Consequences of CK2 signaling to the nuclear matrix.
Title: Consequences of CK2 signaling to the nuclear matrix.

Submit: New GeneRIF Correction

General gene information

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Markers

RH138087 (e-PCR)
- UniSTS:220174

RH143279 (e-PCR)
- UniSTS:232526

RH139043 (e-PCR)
- UniSTS:221129

RH131493 (e-PCR)
- UniSTS:214776

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	NAS Non-traceable Author Statement more info	PubMed
enables double-stranded DNA binding	TAS Traceable Author Statement more info	PubMed
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded DNA binding	TAS Traceable Author Statement more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to X-ray	ISO Inferred from Sequence Orthology more info
involved_in chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in interstrand cross-link repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in interstrand cross-link repair	ISO Inferred from Sequence Orthology more info
involved_in intracellular glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA strand elongation	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in replication fork processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

Names: cyclin-dependent kinase substrate; nuclear ubiquitous casein and cyclin-dependent kinases substrate; nuclear ubiquitous casein and cyclin-dependent kinases substrate-like; nuclear ubiquitous casein kinase 2; nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022799.2 → NP_073636.1 nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

See identical proteins and their annotated locations for NP_073636.1

Status: PROVISIONAL

Source sequence(s)

BC078818

UniProtKB/Swiss-Prot

Q9EPJ0

UniProtKB/TrEMBL

A0A8L2UNR4

Related

ENSRNOP00000065540.3, ENSRNOT00000075674.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

45897275..45926491

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249797.5 → XP_006249859.1 nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform X1

UniProtKB/TrEMBL

A0A8L2UNR4
XM_063272581.1 → XP_063128651.1 nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform X2