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    Arhgef40 Rho guanine nucleotide exchange factor 40 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361034, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Arhgef40provided by RGD
    Official Full Name
    Rho guanine nucleotide exchange factor 40provided by RGD
    Primary source
    RGD:1308093
    See related
    EnsemblRapid:ENSRNOG00000052354 AllianceGenome:RGD:1308093
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308093
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in cytosol and plasma membrane. Orthologous to human ARHGEF40 (Rho guanine nucleotide exchange factor 40). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 279.6), Heart (RPKM 102.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgef40 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (27146155..27170012)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (24672645..24696510)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (28377916..28403090)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ribonuclease A family member 13 Neighboring gene small nuclear ribonucleoprotein polypeptide C, pseudogene 7 Neighboring gene zinc finger protein 219 Neighboring gene transmembrane protein 253 Neighboring gene ribosomal protein L31 like 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 40
    Names
    Rho guanine nucleotide exchange factor (GEF) 40

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271313.1 → NP_001258242.1  rho guanine nucleotide exchange factor 40

      See identical proteins and their annotated locations for NP_001258242.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A0G2JZE7, A0A8I5ZUE2
      Related
      ENSRNOP00000082140.2, ENSRNOT00000104210.2
      Conserved Domains (4) summary
      cd13242
      Location:1241 → 1376
      PH_puratrophin-1; Puratrophin-1 pleckstrin homology (PH) domain
      pfam00169
      Location:1266 → 1364
      PH; PH domain
      cl02488
      Location:789 → 967
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl02571
      Location:1083 → 1242
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      27146155..27170012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093480.2 → XP_038949408.1  rho guanine nucleotide exchange factor 40 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZRN9
      Conserved Domains (3) summary
      PHA03247
      Location:251 → 446
      PHA03247; large tegument protein UL36; Provisional
      cl02488
      Location:789 → 967
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl02571
      Location:1083 → 1242
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    2. XM_039093478.2 → XP_038949406.1  rho guanine nucleotide exchange factor 40 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUE2
      Conserved Domains (4) summary
      PHA03247
      Location:251 → 446
      PHA03247; large tegument protein UL36; Provisional
      cd13242
      Location:1241 → 1376
      PH_puratrophin-1; Puratrophin-1 pleckstrin homology (PH) domain
      cl02488
      Location:789 → 967
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl02571
      Location:1083 → 1242
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    3. XM_063274402.1 → XP_063130472.1  rho guanine nucleotide exchange factor 40 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ARU3

    4. XM_039093479.2 → XP_038949407.1  rho guanine nucleotide exchange factor 40 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZRN9, A0A8I6ARU3
      Related
      ENSRNOP00000096089.1, ENSRNOT00000108540.2
      Conserved Domains (4) summary
      PHA03247
      Location:251 → 446
      PHA03247; large tegument protein UL36; Provisional
      cd13242
      Location:1241 → 1376
      PH_puratrophin-1; Puratrophin-1 pleckstrin homology (PH) domain
      cl02488
      Location:789 → 967
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl02571
      Location:1083 → 1242
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    5. XM_039093477.2 → XP_038949405.1  rho guanine nucleotide exchange factor 40 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUE2
      Conserved Domains (4) summary
      PHA03247
      Location:251 → 446
      PHA03247; large tegument protein UL36; Provisional
      cd13242
      Location:1241 → 1376
      PH_puratrophin-1; Puratrophin-1 pleckstrin homology (PH) domain
      cl02488
      Location:789 → 967
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl02571
      Location:1083 → 1242
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    6. XM_039093476.2 → XP_038949404.1  rho guanine nucleotide exchange factor 40 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUE2
      Conserved Domains (4) summary
      PHA03247
      Location:251 → 446
      PHA03247; large tegument protein UL36; Provisional
      cd13242
      Location:1241 → 1376
      PH_puratrophin-1; Puratrophin-1 pleckstrin homology (PH) domain
      cl02488
      Location:789 → 967
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl02571
      Location:1083 → 1242
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    7. XM_063274401.1 → XP_063130471.1  rho guanine nucleotide exchange factor 40 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JZE7

    8. XM_063274400.1 → XP_063130470.1  rho guanine nucleotide exchange factor 40 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JZE7

    RNA

    1. XR_010057835.1 RNA Sequence

    2. XR_005493755.2 RNA Sequence

    3. XR_010057836.1 RNA Sequence

    4. XR_001841260.3 RNA Sequence

    5. XR_010057837.1 RNA Sequence

    6. XR_010057838.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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