Ptger3 prostaglandin E receptor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptger3provided by RGD
Official Full Name: prostaglandin E receptor 3provided by RGD
Primary source: RGD:3435
See related: EnsemblRapid:ENSRNOG00000010325 AllianceGenome:RGD:3435
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: EP3; EP3R; Rep3; rEP3a; rEP3b
Summary: Enables prostaglandin E receptor activity. Involved in several processes, including negative regulation of G protein-coupled receptor signaling pathway; regulation of circadian sleep/wake cycle; and regulation of secretion. Located in several cellular components, including brush border membrane; nuclear membrane; and proximal neuron projection. Used to study asthma and withdrawal disorder. Biomarker of colon cancer; membranous glomerulonephritis; and renovascular hypertension. Orthologous to human PTGER3 (prostaglandin E receptor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 133.9), Uterus (RPKM 64.0) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q45

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (249264985..249409966)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (246606131..246750970)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (263895093..263979682)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of Prostaglandin E2 Receptor EP3 Attenuates Oxidative Stress and Neuronal Apoptosis Partially by Modulating p38MAPK/FOXO3/Mul1/Mfn2 Pathway after Subarachnoid Hemorrhage in Rats.
Title: Inhibition of Prostaglandin E2 Receptor EP3 Attenuates Oxidative Stress and Neuronal Apoptosis Partially by Modulating p38MAPK/FOXO3/Mul1/Mfn2 Pathway after Subarachnoid Hemorrhage in Rats.
Rat prostaglandin EP3 receptor is highly promiscuous and is the sole prostanoid receptor family member that regulates INS-1 (832/3) cell glucose-stimulated insulin secretion.
Title: Rat prostaglandin EP3 receptor is highly promiscuous and is the sole prostanoid receptor family member that regulates INS-1 (832/3) cell glucose-stimulated insulin secretion.
Role of the PGE2 receptor in ischemia-reperfusion injury of the rat retina.
Title: Role of the PGE2 receptor in ischemia-reperfusion injury of the rat retina.
Results show that prostaglandin E2, via actions of presynaptic EP3 receptors, potently depresses GABA release onto parvocellular neuroendocrine cells.
Title: Prostaglandin E(2) depresses GABA release onto parvocellular neuroendocrine neurones in the paraventricular nucleus of the hypothalamus via presynaptic receptors.
that EP3 might exert its pro-apoptotic function on neuronal apoptosis
Title: EP3, Prostaglandin E2 Receptor Subtype 3, Associated with Neuronal Apoptosis Following Intracerebral Hemorrhage.
EP(3) receptors located presynaptically on sympathetic nerve fibers supplying the heart of pithed rats strongly inhibit the neurogenic tachycardia.
Title: EP₃ receptor-mediated contraction of human pulmonary arteries and inhibition of neurogenic tachycardia in pithed rats.
Inhibition of prostaglandin E receptor 3 (EP) receptors, blocked Ca oscillations in smooth muscle cells and airway contraction induced by local epithelial injury.
Title: Adenosine A(1) and prostaglandin E receptor 3 receptors mediate global airway contraction after local epithelial injury.
Our data suggest that the diabetes-related enhancement of EP3 receptor-mediated vasocontraction results from activation of the PKCdelta pathway.
Title: Protein kinase C delta contributes to increase in EP3 agonist-induced contraction in mesenteric arteries from type 2 diabetic Goto-Kakizaki rats.
The EP(3) mRNA was mainly found in thalamus and hypothalamus in rats.
Title: Prostaglandin E2 receptor expression in the rat trigeminal-vascular system and other brain structures involved in pain.
EP3 receptors were expressed in forebrain neurons and were induced in endothelial cells after hypoxic-ischemic injury in the neonatal rat. Activation by misoprostol reduced the injury.
Title: Function of prostaglandin E2 EP receptors in the acute outcome of rodent hypoxic ischemic encephalopathy.

Submit: New GeneRIF Correction See all GeneRIFs (23)

General gene information

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Markers

RH131341 (e-PCR)
- UniSTS:214624

09.mHAa3d9.seq (e-PCR)
- UniSTS:123004

D17406 (e-PCR)
- UniSTS:159205

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables prostaglandin E receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin E receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin E receptor activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin E receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables prostaglandin E receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bicarbonate transport	ISO Inferred from Sequence Orthology more info
involved_in cAMP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cAMP/PKA signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to forskolin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to prostaglandin E stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in desensitization of G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within fever generation	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in intestine smooth muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intestine smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maternal process involved in parturition	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of circadian sleep/wake cycle, wakefulness	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of forebrain neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gastric acid secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gastrin-induced gastric acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of norepinephrine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of potassium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of small intestine smooth muscle contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcitonin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of colon smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fever generation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gastric mucosal blood circulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inhibitory G protein-coupled receptor phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mucus secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of myofibroblast contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neutrophil extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle contraction involved in micturition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of substance P secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of urine volume	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in prostaglandin receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian sleep/wake cycle, wakefulness	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of norepinephrine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to salt	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in urinary bladder smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in proximal neuron projection	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: prostaglandin E2 receptor EP3 subtype

Names: PGE receptor, EP3 subtype; PGE2 receptor EP3 subtype; prostaglandin E receptor 3 (subtype EP3); prostanoid EP3 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012704.1 → NP_036836.1 prostaglandin E2 receptor EP3 subtype

See identical proteins and their annotated locations for NP_036836.1

Status: PROVISIONAL

Source sequence(s)

D29969

UniProtKB/TrEMBL

A6HWS8, A6HWT0, G3V7D9

Related

ENSRNOP00000102793.1, ENSRNOT00000171890.1

Conserved Domains (1) summary

pfam00001
Location:42 → 323

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

249264985..249409966

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101758.2 → XP_038957686.1 prostaglandin E2 receptor EP3 subtype isoform X4

UniProtKB/Swiss-Prot

P34980, Q63194, Q64376

Related

ENSRNOP00000111351.1, ENSRNOT00000125616.1

Conserved Domains (2) summary

cd14964
Location:27 → 53

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:26 → 335

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_039101754.2 → XP_038957682.1 prostaglandin E2 receptor EP3 subtype isoform X1

UniProtKB/TrEMBL

A6HWT0

Related

ENSRNOP00000014034.6, ENSRNOT00000014034.9

Conserved Domains (2) summary

cd14964
Location:27 → 53

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:26 → 335

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006233535.5 → XP_006233597.1 prostaglandin E2 receptor EP3 subtype isoform X2

See identical proteins and their annotated locations for XP_006233597.1

UniProtKB/Swiss-Prot

P34980, Q63194, Q64376

UniProtKB/TrEMBL

A0A0G2JSK4, A6HWS9

Related

ENSRNOP00000014126.3, ENSRNOT00000014126.7

Conserved Domains (2) summary

cd14964
Location:27 → 53

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:26 → 335

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_039101757.2 → XP_038957685.1 prostaglandin E2 receptor EP3 subtype isoform X3

UniProtKB/TrEMBL

A6HWT0

Related

ENSRNOP00000111877.1, ENSRNOT00000156665.1

Conserved Domains (2) summary

cd14964
Location:27 → 53

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:26 → 335

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily