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    PLDP2 phospholipase D P2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819730, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PLDP2
    Official Full Name
    phospholipase D P2
    Primary source
    TAIR:AT3G05630
    Locus tag
    AT3G05630
    See related
    Araport:AT3G05630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F18C1.10; F18C1_10; PDLZ2; PHOSPHOLIPASE D; phospholipase D P2; PHOSPHOLIPASE D ZETA 2; PLDZETA2
    Summary
    Encodes a member of the PXPH-PLD subfamily of phospholipase D proteins. Regulates vesicle trafficking. Required for auxin transport and distribution and hence auxin responses. This subfamily is novel structurally different from the majority of plant PLDs by having phox homology (PX) and pleckstrin homology (PH) domains. Involved regulating root development in response to nutrient limitation. Plays a major role in phosphatidic acid production during phosphate deprivation. Induced upon Pi starvation in both shoots and roots. Involved in hydrolyzing phosphatidylcholine and phosphatidylethanolamine to produce diacylglycerol for digalactosyldiacylglycerol synthesis and free Pi to sustain other Pi-requiring processes. Does not appear to be involved in root hair patterning. Expression is upregulated in the shoot of cax1/cax3 mutant.
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    Genomic context

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    See PLDP2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    16
    Sequence:
    Chromosome: 3; NC_003074.8 (1635194..1640357)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene Protein phosphatase 2C family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene receptor like protein 32

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of the Arabidopsis PLDZ2 promoter reveals an evolutionarily conserved low-Pi-responsive transcriptional enhancer element. Oropeza-Aburto A, et al. J Exp Bot, 2012 Mar. PMID 22210906, Free PMC Article
    2. Involvement of Arabidopsis thaliana phospholipase Dzeta2 in root hydrotropism through the suppression of root gravitropism. Taniguchi YY, et al. Planta, 2010 Jan. PMID 19915862
    3. Phosphate availability affects the tonoplast localization of PLDzeta2, an Arabidopsis thaliana phospholipase D. Yamaryo Y, et al. FEBS Lett, 2008 Mar 5. PMID 18242181
    4. Arabidopsis PLDζ1 and PLDζ2 localize to post-Golgi membrane compartments in a partially overlapping manner. Shimamura R, et al. Plant Mol Biol, 2022 Jan. PMID 34601701
    5. Phospholipases AtPLDζ1 and AtPLDζ2 function differently in hypoxia. Lindberg S, et al. Physiol Plant, 2018 Jan. PMID 28834646

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis PLDzeta1 and PLDzeta2 localize to post-Golgi membrane compartments in a partially overlapping manner.
      Title: Arabidopsis PLDζ1 and PLDζ2 localize to post-Golgi membrane compartments in a partially overlapping manner.
    2. The efficiency of photosystem II, estimated by measuring the ratio of chlorophyll fluorescence (F v/ m ratio), was strongly decreased in pldzeta1 under salt stress. In conclusion, PLDzeta2 plays a key role in determining Arabidopsis sensitivity to salt stress allowing ion transport and antioxidant responses to be finely regulated.
      Title: Phospholipases Dζ1 and Dζ2 have distinct roles in growth and antioxidant systems in Arabidopsis thaliana responding to salt stress.
    3. AtPLDzeta2 is involved in phosphatidic acids production by a calcium signaling pathway, while AtPLDzeta1 is more important in reactive oxygen species signaling.
      Title: Phospholipases AtPLDζ1 and AtPLDζ2 function differently in hypoxia.
    4. A transcriptional enhancer is present in the PLDZ2 promoter and able to confer Pi responsiveness to a minimal, inactive 35S promoter. This enhancer also shares the cytokinin and sucrose responsive properties observed for the intact PLDZ2 promoter.
      Title: Functional analysis of the Arabidopsis PLDZ2 promoter reveals an evolutionarily conserved low-Pi-responsive transcriptional enhancer element.
    5. A variant of the PHR1 binding site is highly enriched in the Arabidopsis phosphate-responsive phospholipase DZ2 coexpression network.
      Title: A specific variant of the PHR1 binding site is highly enriched in the Arabidopsis phosphate-responsive phospholipase DZ2 coexpression network.
    6. PLDzeta2 responds to drought through ABA signaling in the root cap and accelerates root hydrotropism through the suppression of root gravitropism.
      Title: Involvement of Arabidopsis thaliana phospholipase Dzeta2 in root hydrotropism through the suppression of root gravitropism.
    7. AtPLDzeta2 localizes to the tonoplast and the Nter regulatory domain is sufficient for its sorting. Under phosphate deprivation, AtPLDzeta2 remains located in the tonoplast but its distribution is uneven.
      Title: Phosphate availability affects the tonoplast localization of PLDzeta2, an Arabidopsis thaliana phospholipase D.
    8. pldz2 mutant is defective in the hydrolysis of phospholipids and has a reduced capacity to accumulate galactolipids under limiting Pi conditions
      Title: Phospholipase DZ2 plays an important role in extraplastidic galactolipid biosynthesis and phosphate recycling in Arabidopsis roots.
    9. PLDzeta2 plays a role in regulating root development in response to nutrient limitation.
      Title: Double knockouts of phospholipases Dzeta1 and Dzeta2 in Arabidopsis affect root elongation during phosphate-limited growth but do not affect root hair patterning.
    10. PLDzeta2 and and its product, phosphatidic acid (PA) are required for the normal cycling of PIN2-containing vesicles as well as for function in auxin transport and distribution, and hence auxin responses.
      Title: Arabidopsis PLDzeta2 regulates vesicle trafficking and is required for auxin response.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Pathways from PubChem

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    General gene information

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    NM_111436.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables N-acylphosphatidylethanolamine-specific phospholipase D activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase D activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipase D activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to nitrogen starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to phosphate starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within galactolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phospholipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    phospholipase D P2
    NP_187214.2
    • phospholipase D P2 (PLDP2); FUNCTIONS IN: phospholipase D activity; INVOLVED IN: in 7 processes; LOCATED IN: vacuole; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 4 anthesis; CONTAINS InterPro DOMAIN/s: Phospholipase D, eukaryota (InterPro:IPR016555), Phospholipase D (InterPro:IPR015679), Phospholipase D/Transphosphatidylase (InterPro:IPR001736), Pleckstrin homology (InterPro:IPR001849); BEST Arabidopsis thaliana protein match is: phospholipase D P1 (TAIR:AT3G16785.1); Has 2813 Blast hits to 1615 proteins in 467 species: Archae - 4; Bacteria - 808; Metazoa - 511; Fungi - 591; Plants - 736; Viruses - 0; Other Eukaryotes - 163 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1635194..1640357
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111436.6 → NP_187214.2  phospholipase D P2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187214.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A3KH17, Q7XZQ3, Q9M9W8
      UniProtKB/TrEMBL
      A0A178VFZ7
      Conserved Domains (5) summary
      cd06895
      Location:42 → 205
      PX_PLD; The phosphoinositide binding Phox Homology domain of Phospholipase D
      cd09138
      Location:365 → 510
      PLDc_vPLD1_2_yPLD_like_1; Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
      cd09141
      Location:707 → 891
      PLDc_vPLD1_2_yPLD_like_2; Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
      PLN02866
      Location:39 → 1046
      PLN02866; phospholipase D
      cd01254
      Location:193 → 341
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M9W8.2

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