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    Mcee methylmalonyl CoA epimerase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293829, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mceeprovided by RGD
    Official Full Name
    methylmalonyl CoA epimeraseprovided by RGD
    Primary source
    RGD:1309966
    See related
    EnsemblRapid:ENSRNOG00000016327 AllianceGenome:RGD:1309966
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable methylmalonyl-CoA epimerase activity. Predicted to be involved in L-methylmalonyl-CoA metabolic process. Predicted to be located in mitochondrion. Orthologous to human MCEE (methylmalonyl-CoA epimerase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 285.6), Adrenal (RPKM 268.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mcee in Genome Data Viewer
    Location:
    1q22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (127376311..127399551)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (117964576..117987779)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (125229487..125252692)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene FANCD2 and FANCI associated nuclease 1 Neighboring gene M-phase phosphoprotein 10 Neighboring gene uncharacterized LOC134483612 Neighboring gene amyloid beta precursor protein binding family A member 2 Neighboring gene uncharacterized LOC120097338

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of the human methylmalonyl-CoA racemase gene based on the analysis of prokaryotic gene arrangements. Implications for decoding the human genome. Bobik TA, et al. J Biol Chem, 2001 Oct 5. PMID 11481338
    2. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylmalonyl-CoA epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylmalonyl-CoA epimerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-methylmalonyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-methylmalonyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methylmalonyl-CoA epimerase, mitochondrial
    NP_001099811.1
    XP_038964730.1
    XP_038964737.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106341.1 → NP_001099811.1  methylmalonyl-CoA epimerase, mitochondrial

      Status: PROVISIONAL

      Source sequence(s)
      CH473980
      UniProtKB/TrEMBL
      A0A8I6AMQ5, A6JBL4
      Related
      ENSRNOP00000021884.7, ENSRNOT00000021884.8
      Conserved Domains (1) summary
      TIGR03081
      Location:49 → 177
      metmalonyl_epim; methylmalonyl-CoA epimerase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      127376311..127399551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108802.2 → XP_038964730.1  methylmalonyl-CoA epimerase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I6A417, A6JBL6
      Conserved Domains (1) summary
      cl14632
      Location:49 → 128
      VOC; vicinal oxygen chelate (VOC) family

    2. XM_039108809.2 → XP_038964737.1  methylmalonyl-CoA epimerase, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A6JBL5
      Conserved Domains (1) summary
      cl14632
      Location:49 → 123
      VOC; vicinal oxygen chelate (VOC) family
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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