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    Mtmr12 myotubularin related protein 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310155, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mtmr12provided by RGD
    Official Full Name
    myotubularin related protein 12provided by RGD
    Primary source
    RGD:1307902
    See related
    EnsemblRapid:ENSRNOG00000022929 AllianceGenome:RGD:1307902
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pip3ap
    Summary
    Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be located in sarcomere and sarcoplasmic reticulum. Predicted to be active in cytoplasm. Orthologous to human MTMR12 (myotubularin related protein 12). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 146.6), Kidney (RPKM 129.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mtmr12 in Genome Data Viewer
    Location:
    2q16
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (62950722..63020319)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (61223714..61293270)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (62236497..62305995)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485601 Neighboring gene U6 spliceosomal RNA Neighboring gene zinc finger RNA binding protein Neighboring gene uncharacterized LOC134485602 Neighboring gene uncharacterized LOC120101086 Neighboring gene golgi phosphoprotein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions. Lorenzo O, et al. J Cell Sci, 2006 Jul 15. PMID 16787938
    2. CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Slater LH, et al. Proc Natl Acad Sci U S A, 2013 Jun 11. PMID 23716698, Free PMC Article
    3. Structural Analysis of Hippocampal Kinase Signal Transduction. McClatchy DB, et al. ACS Chem Neurosci, 2018 Dec 19. PMID 30053369, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC109012

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol-3-phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sarcomere IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myotubularin-related protein 12
    Names
    inactive phosphatidylinositol 3-phosphatase 12
    phosphatidylinositol 3-phosphatase-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012077.2 → NP_001012077.1  myotubularin-related protein 12 isoform 2

      See identical proteins and their annotated locations for NP_001012077.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q5FVM6
      Conserved Domains (2) summary
      cl17171
      Location:26 → 192
      PH-like; Pleckstrin homology-like domain
      cl21483
      Location:211 → 497
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    2. NM_001415035.1 → NP_001401964.1  myotubularin-related protein 12 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q5FVM6
      Related
      ENSRNOP00000036677.3, ENSRNOT00000036633.5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      62950722..63020319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102201.2 → XP_038958129.1  myotubularin-related protein 12 isoform X3

      UniProtKB/TrEMBL
      A6KJQ2
      Conserved Domains (2) summary
      cd14594
      Location:57 → 259
      PTP-MTMR12; protein tyrosine phosphatase-like pseudophosphatase domain of myotubularin related phosphoinositide phosphatase 12
      pfam12578
      Location:358 → 482
      3-PAP; Myotubularin-associated protein

    2. XM_017590832.3 → XP_017446321.1  myotubularin-related protein 12 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QJ51

    3. XM_039102200.2 → XP_038958128.1  myotubularin-related protein 12 isoform X2

      Conserved Domains (3) summary
      cd14594
      Location:109 → 311
      PTP-MTMR12; protein tyrosine phosphatase-like pseudophosphatase domain of myotubularin related phosphoinositide phosphatase 12
      pfam12578
      Location:410 → 534
      3-PAP; Myotubularin-associated protein
      cl17171
      Location:14 → 40
      PH-like; Pleckstrin homology-like domain

    4. XM_039102202.2 → XP_038958130.1  myotubularin-related protein 12 isoform X3

      UniProtKB/TrEMBL
      A6KJQ2
      Conserved Domains (2) summary
      cd14594
      Location:57 → 259
      PTP-MTMR12; protein tyrosine phosphatase-like pseudophosphatase domain of myotubularin related phosphoinositide phosphatase 12
      pfam12578
      Location:358 → 482
      3-PAP; Myotubularin-associated protein

    5. XM_039102203.2 → XP_038958131.1  myotubularin-related protein 12 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZUA7
      Related
      ENSRNOP00000082096.1, ENSRNOT00000114002.2
      Conserved Domains (2) summary
      pfam12578
      Location:234 → 358
      3-PAP; Myotubularin-associated protein
      cl28904
      Location:2 → 135
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FVM6.2 GenPept UniProtKB/Swiss-Prot:Q5FVM6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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