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    Uxs1 UDP-glucuronate decarboxylase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246232, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Uxs1provided by RGD
    Official Full Name
    UDP-glucuronate decarboxylase 1provided by RGD
    Primary source
    RGD:628680
    See related
    EnsemblRapid:ENSRNOG00000045605 AllianceGenome:RGD:628680
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    UGD
    Summary
    Enables UDP-glucuronate decarboxylase activity. Predicted to be involved in UDP-D-xylose biosynthetic process. Located in Golgi membrane. Orthologous to human UXS1 (UDP-glucuronate decarboxylase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 82.2), Thymus (RPKM 69.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Uxs1 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (740929..818310)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (653740..731121)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (11165006..11240329, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480466 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene ribosomal protein S8, pseudogene 14 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene zinc finger protein 119b like Neighboring gene ribosomal protein S21, pseudogene 2 Neighboring gene Epstein-Barr virus induced 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human UDP-α-d-xylose synthase forms a catalytically important tetramer that has not been observed in crystal structures. Polizzi SJ, et al. Biochemistry, 2013 Jun 4. PMID 23656592
    2. Human UDP-α-D-xylose synthase and Escherichia coli ArnA conserve a conformational shunt that controls whether xylose or 4-keto-xylose is produced. Polizzi SJ, et al. Biochemistry, 2012 Nov 6. PMID 23072385, Free PMC Article
    3. UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization. Moriarity JL, et al. J Biol Chem, 2002 May 10. PMID 11877387
    4. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization.
      Title: UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC93157

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD+ binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UDP-glucuronate decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glucuronate decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-glucuronate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glucuronate decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-xylose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UDP-D-xylose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UDP-D-xylose biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catalytic complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    UDP-glucuronic acid decarboxylase 1
    Names
    UXS-1
    NP_647552.2
    XP_006244358.1
    XP_008764973.1
    XP_017451760.1
    XP_017451761.1
    XP_017451763.1
    XP_038938947.1
    XP_038938950.1
    XP_038938951.1
    XP_063122704.1
    XP_063122705.1
    XP_063122706.1
    XP_063122708.1
    XP_063122709.1
    XP_063122710.1
    XP_063122711.1
    XP_063122712.1
    XP_063122714.1
    XP_063122715.1
    XP_063122716.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139336.2 → NP_647552.2  UDP-glucuronic acid decarboxylase 1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q5PQX0, Q8K464
      UniProtKB/TrEMBL
      A0A8I6AAA1, A6KR28
      Related
      ENSRNOP00000070855.3, ENSRNOT00000082837.3
      Conserved Domains (2) summary
      cd05230
      Location:89 → 392
      UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
      pfam11803
      Location:4 → 78
      UXS1_N; UDP-glucuronate decarboxylase N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      740929..818310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266642.1 → XP_063122712.1  UDP-glucuronic acid decarboxylase 1 isoform X13

    2. XM_063266635.1 → XP_063122705.1  UDP-glucuronic acid decarboxylase 1 isoform X2

    3. XM_063266646.1 → XP_063122716.1  UDP-glucuronic acid decarboxylase 1 isoform X12

    4. XM_063266636.1 → XP_063122706.1  UDP-glucuronic acid decarboxylase 1 isoform X3

    5. XM_063266645.1 → XP_063122715.1  UDP-glucuronic acid decarboxylase 1 isoform X12

    6. XM_006244296.5 → XP_006244358.1  UDP-glucuronic acid decarboxylase 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AAA1, A0A8L2R317
      Related
      ENSRNOP00000066044.4, ENSRNOT00000070920.4
      Conserved Domains (2) summary
      cd05230
      Location:94 → 397
      UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
      pfam11803
      Location:4 → 83
      UXS1_N; UDP-glucuronate decarboxylase N-terminal

    7. XM_039083023.2 → XP_038938951.1  UDP-glucuronic acid decarboxylase 1 isoform X14

      UniProtKB/TrEMBL
      A0A8L2QX18
      Conserved Domains (1) summary
      cd05230
      Location:1 → 284
      UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs

    8. XM_039083022.2 → XP_038938950.1  UDP-glucuronic acid decarboxylase 1 isoform X15

      Conserved Domains (2) summary
      cd05230
      Location:24 → 271
      UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
      pfam11803
      Location:4 → 31
      UXS1_N; UDP-glucuronate decarboxylase N-terminal

    9. XM_017596274.3 → XP_017451763.1  UDP-glucuronic acid decarboxylase 1 isoform X14

      UniProtKB/TrEMBL
      A0A8L2QX18
      Conserved Domains (1) summary
      cd05230
      Location:1 → 284
      UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs

    10. XM_008766751.3 → XP_008764973.1  UDP-glucuronic acid decarboxylase 1 isoform X4

      UniProtKB/TrEMBL
      A0A8L2QX18
      Related
      ENSRNOP00000094146.2, ENSRNOT00000094164.2
      Conserved Domains (3) summary
      cd05230
      Location:112 → 415
      UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
      COG0451
      Location:112 → 419
      WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]
      pfam11803
      Location:48 → 101
      UXS1_N; UDP-glucuronate decarboxylase N-terminal

    11. XM_039083019.2 → XP_038938947.1  UDP-glucuronic acid decarboxylase 1 isoform X5

      UniProtKB/TrEMBL
      A0A8L2QX18
      Related
      ENSRNOP00000076956.2, ENSRNOT00000098406.2
      Conserved Domains (2) summary
      cd05230
      Location:107 → 410
      UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
      pfam11803
      Location:48 → 96
      UXS1_N; UDP-glucuronate decarboxylase N-terminal

    12. XM_017596271.2 → XP_017451760.1  UDP-glucuronic acid decarboxylase 1 isoform X10

      UniProtKB/TrEMBL
      A0A8I6AIX5, A0A8L2QX18
      Related
      ENSRNOP00000095660.2, ENSRNOT00000119230.2
      Conserved Domains (2) summary
      cd05230
      Location:76 → 379
      UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
      pfam11803
      Location:15 → 65
      UXS1_N; UDP-glucuronate decarboxylase N-terminal

    13. XM_017596272.3 → XP_017451761.1  UDP-glucuronic acid decarboxylase 1 isoform X11

      UniProtKB/TrEMBL
      A0A8L2QX18
      Conserved Domains (2) summary
      cd05230
      Location:71 → 374
      UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
      pfam11803
      Location:15 → 60
      UXS1_N; UDP-glucuronate decarboxylase N-terminal

    14. XM_063266634.1 → XP_063122704.1  UDP-glucuronic acid decarboxylase 1 isoform X1

      Related
      ENSRNOP00000099474.1, ENSRNOT00000164338.1

    15. XM_063266638.1 → XP_063122708.1  UDP-glucuronic acid decarboxylase 1 isoform X6

    16. XM_063266639.1 → XP_063122709.1  UDP-glucuronic acid decarboxylase 1 isoform X7

    17. XM_063266641.1 → XP_063122711.1  UDP-glucuronic acid decarboxylase 1 isoform X12

    18. XM_063266640.1 → XP_063122710.1  UDP-glucuronic acid decarboxylase 1 isoform X9

    19. XM_063266644.1 → XP_063122714.1  UDP-glucuronic acid decarboxylase 1 isoform X16

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PQX0.1 GenPept UniProtKB/Swiss-Prot:Q5PQX0

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