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    Atp6v1c2 ATPase H+ transporting V1 subunit C2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362802, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Atp6v1c2provided by RGD
    Official Full Name
    ATPase H+ transporting V1 subunit C2provided by RGD
    Primary source
    RGD:1359430
    See related
    EnsemblRapid:ENSRNOG00000050553 AllianceGenome:RGD:1359430
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in positive regulation of Wnt signaling pathway. Predicted to act upstream of or within proton transmembrane transport. Predicted to be part of vacuolar proton-transporting V-type ATPase, V1 domain. Orthologous to human ATP6V1C2 (ATPase H+ transporting V1 subunit C2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 207.5), Kidney (RPKM 81.2) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atp6v1c2 in Genome Data Viewer
    Location:
    6q16
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (45809269..45872914, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (40080545..40144199, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (42585452..42632289, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel modifier subfamily F member 1 Neighboring gene protein disulfide isomerase family A, member 6 Neighboring gene nucleolar protein 10 Neighboring gene craniofacial development protein 1 like 1 Neighboring gene proteasome activator subunit 3, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differential expression of a V-type ATPase C subunit gene, Atp6v1c2, during culture of rat lung type II pneumocytes. Feng NH, et al. J Biomed Sci, 2005 Dec. PMID 16283434
    2. Expression, purification and characterization of isoforms of peripheral stalk subunits of human V-ATPase. Rahman S, et al. Protein Expr Purif, 2011 Aug. PMID 21356312
    3. Mouse proton pump ATPase C subunit isoforms (C2-a and C2-b) specifically expressed in kidney and lung. Sun-Wada GH, et al. J Biol Chem, 2003 Nov 7. PMID 12947086
    4. Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling. Cruciat CM, et al. Science, 2010 Jan 22. PMID 20093472
    5. Diversity of mouse proton-translocating ATPase: presence of multiple isoforms of the C, d and G subunits. Sun-Wada GH, et al. Gene, 2003 Jan 2. PMID 12527205

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of V-type ATPase C subunit gene, Atp6v1c2, during culture of rat lung type II pneumocytes
      Title: Differential expression of a V-type ATPase C subunit gene, Atp6v1c2, during culture of rat lung type II pneumocytes.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of proton-transporting V-type ATPase, V1 domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V1 domain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    V-type proton ATPase subunit C 2
    Names
    ATPase, H+ transporting, V1 subunit C
    ATPase, H+ transporting, lysosomal V1 subunit C2
    V-ATPase subunit C 2
    vacuolar H+ ATPase C2
    vacuolar proton pump subunit C 2
    NP_001014221.1
    XP_017449730.2
    XP_038968527.1
    XP_038968528.1
    XP_038968532.1
    XP_038968535.1
    XP_063118235.1
    XP_063118236.1
    XP_063118237.1
    XP_063118238.1
    XP_063118239.1
    XP_063118240.1
    XP_063118241.1
    XP_063118242.1
    XP_063118243.1
    XP_063118244.1
    XP_063118245.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014199.1 → NP_001014221.1  V-type proton ATPase subunit C 2

      See identical proteins and their annotated locations for NP_001014221.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079083
      UniProtKB/Swiss-Prot
      Q53B80, Q6AYE4
      UniProtKB/TrEMBL
      A0A0G2JZN3
      Related
      ENSRNOP00000066981.3, ENSRNOT00000071977.4
      Conserved Domains (2) summary
      cd14785
      Location:55 → 75
      V-ATPase_C; 3-helical coiled coil [structural motif]
      pfam03223
      Location:5 → 415
      V-ATPase_C; V-ATPase subunit C

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      45809269..45872914 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262173.1 → XP_063118243.1  V-type proton ATPase subunit C 2 isoform X4

      Related
      ENSRNOP00000093823.1, ENSRNOT00000099858.2

    2. XM_063262171.1 → XP_063118241.1  V-type proton ATPase subunit C 2 isoform X3

    3. XM_039112600.2 → XP_038968528.1  V-type proton ATPase subunit C 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JZN3
      Conserved Domains (2) summary
      cd14785
      Location:55 → 98
      V-ATPase_C; 3-helical coiled coil [structural motif]
      pfam03223
      Location:5 → 438
      V-ATPase_C; V-ATPase subunit C

    4. XM_039112604.2 → XP_038968532.1  V-type proton ATPase subunit C 2 isoform X2

      UniProtKB/Swiss-Prot
      Q53B80, Q6AYE4
      UniProtKB/TrEMBL
      A0A0G2JZN3
      Conserved Domains (2) summary
      cd14785
      Location:55 → 75
      V-ATPase_C; 3-helical coiled coil [structural motif]
      pfam03223
      Location:5 → 415
      V-ATPase_C; V-ATPase subunit C

    5. XM_039112599.2 → XP_038968527.1  V-type proton ATPase subunit C 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JZN3
      Conserved Domains (2) summary
      cd14785
      Location:55 → 98
      V-ATPase_C; 3-helical coiled coil [structural motif]
      pfam03223
      Location:5 → 438
      V-ATPase_C; V-ATPase subunit C

    6. XM_063262167.1 → XP_063118237.1  V-type proton ATPase subunit C 2 isoform X2

      UniProtKB/Swiss-Prot
      Q53B80, Q6AYE4

    7. XM_063262174.1 → XP_063118244.1  V-type proton ATPase subunit C 2 isoform X4

    8. XM_063262165.1 → XP_063118235.1  V-type proton ATPase subunit C 2 isoform X1

    9. XM_063262170.1 → XP_063118240.1  V-type proton ATPase subunit C 2 isoform X3

    10. XM_063262169.1 → XP_063118239.1  V-type proton ATPase subunit C 2 isoform X2

      UniProtKB/Swiss-Prot
      Q53B80, Q6AYE4

    11. XM_063262175.1 → XP_063118245.1  V-type proton ATPase subunit C 2 isoform X4

    12. XM_063262172.1 → XP_063118242.1  V-type proton ATPase subunit C 2 isoform X4

    13. XM_063262166.1 → XP_063118236.1  V-type proton ATPase subunit C 2 isoform X2

      UniProtKB/Swiss-Prot
      Q53B80, Q6AYE4

    14. XM_017594241.3 → XP_017449730.2  V-type proton ATPase subunit C 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JZN3
      Conserved Domains (2) summary
      cd14785
      Location:55 → 98
      V-ATPase_C; 3-helical coiled coil [structural motif]
      pfam03223
      Location:5 → 438
      V-ATPase_C; V-ATPase subunit C

    15. XM_063262168.1 → XP_063118238.1  V-type proton ATPase subunit C 2 isoform X2

      UniProtKB/Swiss-Prot
      Q53B80, Q6AYE4

    16. XM_039112607.2 → XP_038968535.1  V-type proton ATPase subunit C 2 isoform X5

      UniProtKB/TrEMBL
      M0RBN8
      Conserved Domains (2) summary
      cd14785
      Location:76 → 102
      V-ATPase_C; 3-helical coiled coil [structural motif]
      pfam03223
      Location:22 → 371
      V-ATPase_C; V-ATPase subunit C
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYE4.1 GenPept UniProtKB/Swiss-Prot:Q6AYE4

    Gene LinkOut

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