Pds5a PDS5 cohesin associated factor A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pds5aprovided by RGD
Official Full Name: PDS5 cohesin associated factor Aprovided by RGD
Primary source: RGD:1307094
See related: EnsemblRapid:ENSRNOG00000002541 AllianceGenome:RGD:1307094
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Scc-112; RGD1307094
Summary: Predicted to be involved in DNA repair; mitotic sister chromatid cohesion; and negative regulation of DNA replication. Predicted to act upstream of or within several processes, including lens development in camera-type eye; neuroblast migration; and roof of mouth development. Predicted to be located in chromatin; nucleoplasm; and plasma membrane. Predicted to be active in nucleus. Orthologous to human PDS5A (PDS5 cohesin associated factor A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 354.9), Spleen (RPKM 270.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p11

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (42905734..43004740)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (42551653..42651074)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (44185445..44282308)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that the siRNA-mediated knockdown of Pds5A affects sister chromatid cohesion but does not influence mitotic checkpoint function or the proliferation and survival of glioblastoma multiforme cells.
Title: The cohesin-interacting protein, precocious dissociation of sisters 5A/sister chromatid cohesion protein 112, is up-regulated in human astrocytic tumors.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lens development in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within metanephros development	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic sister chromatid cohesion	IEA Inferred from Electronic Annotation more info
involved_in mitotic sister chromatid cohesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA replication	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA replication	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neuroblast migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within roof of mouth development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sister chromatid cohesion protein PDS5 homolog A

Names: PDS5, regulator of cohesion maintenance, homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083624.1 → NP_001077093.1 sister chromatid cohesion protein PDS5 homolog A

See identical proteins and their annotated locations for NP_001077093.1

Status: PROVISIONAL

Source sequence(s)

EF460313

UniProtKB/Swiss-Prot

A4L9P7

Related

ENSRNOP00000003437.7, ENSRNOT00000003437.8

Conserved Domains (2) summary

sd00044
Location:282 → 312

HEAT; HEAT repeat [structural motif]

cd19953
Location:40 → 670

PDS5; Sister chromatid cohesion protein PDS5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

42905734..43004740

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091918.2 → XP_038947846.1 sister chromatid cohesion protein PDS5 homolog A isoform X1

UniProtKB/TrEMBL

A0A8L2Q0A3, A6JDD2

Related

ENSRNOP00000107870.1, ENSRNOT00000143027.1

Conserved Domains (2) summary

sd00044
Location:282 → 312

HEAT; HEAT repeat [structural motif]

cd19953
Location:40 → 670

PDS5; Sister chromatid cohesion protein PDS5
XM_063273132.1 → XP_063129202.1 sister chromatid cohesion protein PDS5 homolog A isoform X3
XM_063273131.1 → XP_063129201.1 sister chromatid cohesion protein PDS5 homolog A isoform X2

UniProtKB/Swiss-Prot

A4L9P7
XM_063273133.1 → XP_063129203.1 sister chromatid cohesion protein PDS5 homolog A isoform X4