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    Dnajc1 DnaJ heat shock protein family (Hsp40) member C1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100360412, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dnajc1provided by RGD
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C1provided by RGD
    Primary source
    RGD:2322144
    See related
    EnsemblRapid:ENSRNOG00000000150 AllianceGenome:RGD:2322144
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in regulation of protein secretion. Predicted to act upstream of or within protein folding and regulation of translation. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be active in endomembrane system. Orthologous to human DNAJC1 (DnaJ heat shock protein family (Hsp40) member C1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 129.9), Spleen (RPKM 105.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnajc1 in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (85863651..86020954, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (80955209..81112025, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (84986994..85141464, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108353137 Neighboring gene SKI/DACH domain containing 1 Neighboring gene MLLT10, histone lysine methyltransferase DOT1L cofactor Neighboring gene uncharacterized LOC108348596 Neighboring gene uncharacterized LOC134482756 Neighboring gene uncharacterized LOC134482757 Neighboring gene ATP-dependent RNA helicase DDX39A-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity. Kroczynska B, et al. J Biol Chem, 2004 Mar 19. PMID 14668352, Free PMC Article
    2. Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex. Nakatsuka A, et al. Diabetes, 2012 Nov. PMID 22837305, Free PMC Article
    3. A novel type of co-chaperone mediates transmembrane recruitment of DnaK-like chaperones to ribosomes. Dudek J, et al. EMBO J, 2002 Jun 17. PMID 12065409, Free PMC Article
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein folding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 1
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 1
    DnaJ (Hsp40) homolog, subfamily C, member 1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001400837.1 → NP_001387766.1  dnaJ homolog subfamily C member 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6JM90, F1LVX1
      Related
      ENSRNOP00000000162.7, ENSRNOT00000000162.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      85863651..86020954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096460.2 → XP_038952388.1  dnaJ homolog subfamily C member 1 isoform X2

      Conserved Domains (1) summary
      cd00167
      Location:269 → 316
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    2. XM_039096459.2 → XP_038952387.1  dnaJ homolog subfamily C member 1 isoform X1

      Conserved Domains (1) summary
      pfam00226
      Location:72 → 133
      DnaJ; DnaJ domain
    Nucleotide Protein Strain
    Heading Accession and Version

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