Erbin erbb2 interacting protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Erbinprovided by RGD
Official Full Name: erbb2 interacting proteinprovided by RGD
Primary source: RGD:1562952
See related: EnsemblRapid:ENSRNOG00000047137 AllianceGenome:RGD:1562952
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Erbb2i; Erbb2ip; RGD1562952
Summary: Predicted to enable protein kinase binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including negative regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway; protein localization to postsynapse; and regulation of gene expression. Predicted to act upstream of or within protein targeting. Is active in glutamatergic synapse; neuromuscular junction; and postsynaptic specialization. Orthologous to human ERBIN (erbb2 interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 602.5), Lung (RPKM 563.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q13

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (36660399..36762584, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (34926962..35028440, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (33880860..33952806, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G07329 (e-PCR)
- UniSTS:42247

RH131798 (e-PCR)
- UniSTS:215081

D2Rat11 (e-PCR)
- UniSTS:118654

RH128622 (e-PCR)
- UniSTS:211930

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of monocyte chemotactic protein-1 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter receptor transport postsynaptic membrane to endosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein targeting	ISO Inferred from Sequence Orthology more info
involved_in receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to muramyl dipeptide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in hemidesmosome	ISO Inferred from Sequence Orthology more info
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic specialization	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic specialization	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: erbin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427815.1 → NP_001414744.1 erbin

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I5ZWX2

Related

ENSRNOP00000083915.1, ENSRNOT00000118358.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

36660399..36762584 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063282246.1 → XP_063138316.1 erbin isoform X9
XM_063282245.1 → XP_063138315.1 erbin isoform X7
XM_063282244.1 → XP_063138314.1 erbin isoform X5
XM_017591180.3 → XP_017446669.2 erbin isoform X2

UniProtKB/TrEMBL

A0A8I5ZN42

Conserved Domains (3) summary

COG4886
Location:70 → 402

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1351 → 1437

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:24 → 47

LRR_RI; leucine-rich repeat [structural motif]
XM_039103492.2 → XP_038959420.1 erbin isoform X8

UniProtKB/TrEMBL

A0A8I5ZN42, A0A8I6A8N1

Related

ENSRNOP00000088858.1, ENSRNOT00000095613.2

Conserved Domains (3) summary

COG4886
Location:70 → 402

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1205 → 1290

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:24 → 47

LRR_RI; leucine-rich repeat [structural motif]
XM_017591184.3 → XP_017446673.2 erbin isoform X6

UniProtKB/TrEMBL

A0A8I5ZN42, A0A8I6ACI5

Related

ENSRNOP00000091667.1, ENSRNOT00000098587.2

Conserved Domains (3) summary

COG4886
Location:70 → 402

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1273 → 1359

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:24 → 47

LRR_RI; leucine-rich repeat [structural motif]
XM_017591181.3 → XP_017446670.2 erbin isoform X3

UniProtKB/TrEMBL

A0A8I5ZN42

Related

ENSRNOP00000066263.4, ENSRNOT00000075196.5

Conserved Domains (3) summary

COG4886
Location:70 → 402

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1321 → 1407

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:24 → 47

LRR_RI; leucine-rich repeat [structural motif]
XM_039103490.2 → XP_038959418.1 erbin isoform X1

UniProtKB/TrEMBL

A0A8I5ZN42, A0A8I6AE43

Related

ENSRNOP00000090634.1, ENSRNOT00000096272.2

Conserved Domains (3) summary

COG4886
Location:70 → 402

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1360 → 1446

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:24 → 47

LRR_RI; leucine-rich repeat [structural motif]
XM_063282243.1 → XP_063138313.1 erbin isoform X4

UniProtKB/TrEMBL

A0A8I5ZWX2
XM_017591179.3 → XP_017446668.2 erbin isoform X1

UniProtKB/TrEMBL

A0A8I5ZN42, A0A8I6AE43

Conserved Domains (3) summary

COG4886
Location:70 → 402

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1360 → 1446

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:24 → 47

LRR_RI; leucine-rich repeat [structural motif]
XM_039103491.2 → XP_038959419.1 erbin isoform X1

UniProtKB/TrEMBL

A0A8I5ZN42, A0A8I6AE43

Conserved Domains (3) summary

COG4886
Location:70 → 402

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1360 → 1446

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:24 → 47

LRR_RI; leucine-rich repeat [structural motif]
XM_063282247.1 → XP_063138317.1 erbin isoform X10