B4galt1 beta-1,4-galactosyltransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: B4galt1provided by RGD
Official Full Name: beta-1,4-galactosyltransferase 1provided by RGD
Primary source: RGD:620900
See related: EnsemblRapid:ENSRNOG00000059461 AllianceGenome:RGD:620900
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ggtb2
Summary: Predicted to enable several functions, including UDP-galactosyltransferase activity; manganese ion binding activity; and tubulin binding activity. Predicted to be involved in lipid metabolic process; positive regulation of circulating fibrinogen levels; and protein N-linked glycosylation. Predicted to act upstream of or within several processes, including binding activity of sperm to zona pellucida; lactose biosynthetic process; and regulation of epithelial cell proliferation. Predicted to be located in several cellular components, including Golgi trans cisterna; basolateral plasma membrane; and brush border membrane. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and congenital disorder of glycosylation type IId. Orthologous to human B4GALT1 (beta-1,4-galactosyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 196.3), Lung (RPKM 140.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (60731601..60778456, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (55935614..55982461, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (57121768..57168610, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

beta-1,4-GalT-I may be an inflammatory mediator regulating adhesion & migration of inflammatory cells in EAE by modifying galactosylated carbohydrate chains to modulate selectin-ligand biosynthesis & interaction with E-selectin.
Title: Upregulation of β-1,4-galactosyltransferase I in rat spinal cord with experimental autoimmune encephalomyelitis.
The expression of the beta-1,4-GalT V gene has been shown to be regulated by transcription factors Sp1 and Ets-1 in cancer cells.(review)
Title: [Regulation of human β-1,4-galactosyltransferase V gene expression in cancer cells].
These findings indicated that the functional interaction between CDK11(p58) and beta-1,4-GalT-I may play an important role during astrocyte activation after LPS administration.
Title: The functional interaction between CDK11p58 and β-1,4-galactosyltransferase I involved in astrocyte activation caused by lipopolysaccharide.
B4galt1 may play an important role in Schwann cell proliferation and apoptosis induced by tumor necrosis factor-alpha via different signal pathways and tumor necrosis factor receptors.
Title: β-1,4-Galactosyltransferase I involved in Schwann cells proliferation and apoptosis induced by tumor necrosis factor-alpha via the activation of MAP kinases signal pathways.
Data suggest that during Schwann cell activation, beta-1,4-galactosyltransferase I may play an important role in the release of inflammatory mediators such as TNF-alpha.
Title: β-1,4-galactosyltransferase I promotes tumor necrosis factor-α autocrine via the activation of MAP kinase signal pathways in Schwann cells.
Data show that SSeCKS can regulate LPS-induced TNF-alpha secretion through beta-1,4-GalT-I in rat primary astrocytes.
Title: The relationship between Src-suppressed C kinase substrate and β-1,4 galactosyltransferase-I in the process of lipopolysaccharide-induced TNF-α secretion in rat primary astrocytes.
beta1,4-GalT-I may play an important role in the inflammation process of rheumatoid arthritis synovial tissue
Title: β1,4-galactosyltransferase-I in synovial tissue of collagen-induced rat model of rheumatoid arthritis.
beta1,4-GalT I and V might play important roles in the regeneration of the injured sciatic nerve.
Title: Expression change of beta-1,4 galactosyltransferase I, V mRNAs and Galbeta1,4GlcNAc group in rat sciatic nerve after crush.
real-time PCR revealed that the beta-1,4-GalT I mRNA reached peaks at 2 weeks after sciatic nerve crush and 3 days after sciatic nerve transection
Title: Expression of beta-1,4-galactosyltransferase I in rat Schwann cells.
beta1,4-GalT-I may play an important role in regulating immune cell migration into the inflammatory site.
Title: Elevated beta1,4-galactosyltransferase-I induced by the intraspinal injection of lipopolysaccharide.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Markers

RH142957 (e-PCR)
- UniSTS:232204

AU046353 (e-PCR)
- UniSTS:111522

d5mit1 (e-PCR)
- UniSTS:122063

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acetyllactosamine synthase activity	IEA Inferred from Electronic Annotation more info
enables N-acetyllactosamine synthase activity	ISO Inferred from Sequence Orthology more info
enables UDP-galactosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables UDP-galactosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info
enables galactosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lactose synthase activity	IEA Inferred from Electronic Annotation more info
enables lactose synthase activity	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acute inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within acute inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis involved in wound healing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis involved in wound healing	ISO Inferred from Sequence Orthology more info
involved_in binding of sperm to zona pellucida	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within binding of sperm to zona pellucida	ISO Inferred from Sequence Orthology more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in development of secondary sexual characteristics	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within development of secondary sexual characteristics	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epithelial cell development	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in galactose metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within galactose metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycoprotein biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in lactose biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lactose biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in lactose biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in macrophage migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within macrophage migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oligosaccharide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in oligosaccharide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in oligosaccharide biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in penetration of zona pellucida	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within penetration of zona pellucida	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of circulating fibrinogen levels	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of circulating fibrinogen levels	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of circulating fibrinogen levels	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epithelial cell proliferation involved in wound healing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in wound healing	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation	IEA Inferred from Electronic Annotation more info
involved_in protein N-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein glycosylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of acrosome reaction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of acrosome reaction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi trans cisterna	IEA Inferred from Electronic Annotation more info
located_in Golgi trans cisterna	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	IEA Inferred from Electronic Annotation more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in desmosome	IEA Inferred from Electronic Annotation more info
located_in desmosome	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: beta-1,4-galactosyltransferase 1

Names: Glycoprotein-4-beta-galactosyltransferase 2; N-acetyllactosamine synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1; b4Gal-T1; beta-1,4-GalTase 1; beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; beta4Gal-T1; lactose synthase A protein; nal synthase; neolactotriaosylceramide beta-1,4-galactosyltransferase

NP_445739.1

EC 2.4.1.22

EC 2.4.1.275

EC 2.4.1.38

EC 2.4.1.90

XP_038965187.1

EC 2.4.1.22

EC 2.4.1.275

EC 2.4.1.38

EC 2.4.1.90

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053287.1 → NP_445739.1 beta-1,4-galactosyltransferase 1

See identical proteins and their annotated locations for NP_445739.1

Status: VALIDATED

Source sequence(s)

AA818683, AA956551, AI709691, CB736416, CB741712, CK364907

UniProtKB/TrEMBL

A6IIS3, A6IIS4, G3V722

Related

ENSRNOP00000069825.1, ENSRNOT00000090499.3

Conserved Domains (1) summary

cd00899
Location:176 → 394

b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

60731601..60778456 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109259.2 → XP_038965187.1 beta-1,4-galactosyltransferase 1 isoform X1

Conserved Domains (1) summary

pfam13733
Location:131 → 217

Glyco_transf_7N; N-terminal region of glycosyl transferase group 7