Pgpep1 pyroglutamyl-peptidase I [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pgpep1provided by RGD
Official Full Name: pyroglutamyl-peptidase Iprovided by RGD
Primary source: RGD:1303133
See related: EnsemblRapid:ENSRNOG00000019657 AllianceGenome:RGD:1303133
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PAPI
Summary: Enables peptidase activity. Involved in protein catabolic process. Predicted to be located in cytosol. Orthologous to human PGPEP1 (pyroglutamyl-peptidase I). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 1611.9), Liver (RPKM 468.3) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (18804408..18817466)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (18770563..18782968)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (20521989..20531254)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PAP-I and PAP-II expression was induced by the decreased dopamine levels in the intermediate lobe of the pituitary under continuous stress.
Title: Continuous stress-induced dopamine dysregulation augments PAP-I and PAP-II expression in melanotrophs of the pituitary gland.
Significant correlation between Pcp activity and the number and size of tumours and the body weight of the animals. Decreased Pcp may reflect increase in circulating GnRH leading to increase in gonadal steroid hormones.
Title: Serum pyrrolidone carboxypeptidase activity in N-methyl-nitrosourea induced rat breast cancer.
Pyroglutamyl aminopeptidase Type-1 shows differentiated activity in various parts of the brain under varied conditions of hydration in rats.
Title: Effect of the disruption of body fluid balance on pyroglutamyl aminopeptidase (Type-1) in rat brain structures.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables pyroglutamyl-peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pyroglutamyl-peptidase 1

Names: 5-oxoprolyl-peptidase; PAP-I; PGP-I; pyroglutamyl aminopeptidase I; pyrrolidone-carboxylate peptidase

NP_973717.1

EC 3.4.19.3

XP_038950248.1

EC 3.4.19.3

XP_063131229.1

EC 3.4.19.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201988.2 → NP_973717.1 pyroglutamyl-peptidase 1

See identical proteins and their annotated locations for NP_973717.1

Status: PROVISIONAL

Source sequence(s)

BC098645

UniProtKB/Swiss-Prot

Q76IC5

UniProtKB/TrEMBL

A0A8I6B2L0, A6KA15

Related

ENSRNOP00000026601.3, ENSRNOT00000026601.5

Conserved Domains (1) summary

cd00501
Location:6 → 199

Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

18804408..18817466

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094320.2 → XP_038950248.1 pyroglutamyl-peptidase 1 isoform X1

Conserved Domains (1) summary

cl00237
Location:1 → 122

Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...
XM_063275159.1 → XP_063131229.1 pyroglutamyl-peptidase 1 isoform X1