Tmem106a transmembrane protein 106A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmem106aprovided by RGD
Official Full Name: transmembrane protein 106Aprovided by RGD
Primary source: RGD:1309043
See related: EnsemblRapid:ENSRNOG00000023628 AllianceGenome:RGD:1309043
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309043
Summary: Predicted to be involved in several processes, including glycoprotein biosynthetic process; positive regulation of intracellular signal transduction; and positive regulation of macromolecule biosynthetic process. Predicted to be located in plasma membrane. Orthologous to human TMEM106A (transmembrane protein 106A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 353.3), Adrenal (RPKM 73.9) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (87007144..87016161)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (86506908..86515915)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (89484269..89493288)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in CD80 biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in CD80 biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in CD86 biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in CD86 biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in macrophage activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MHC class II biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MHC class II biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of nitric oxide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: transmembrane protein 106A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024967.1 → NP_001020138.1 transmembrane protein 106A

See identical proteins and their annotated locations for NP_001020138.1

Status: PROVISIONAL

Source sequence(s)

BC091170

UniProtKB/Swiss-Prot

Q5BK83

UniProtKB/TrEMBL

A0A8I5ZLV0, A6HJD7

Conserved Domains (1) summary

pfam07092
Location:27 → 251

DUF1356; Protein of unknown function (DUF1356)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

87007144..87016161

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268744.1 → XP_063124814.1 transmembrane protein 106A isoform X2

UniProtKB/Swiss-Prot

Q5BK83

UniProtKB/TrEMBL

A6HJD7
XM_008767978.3 → XP_008766200.1 transmembrane protein 106A isoform X1

See identical proteins and their annotated locations for XP_008766200.1

UniProtKB/TrEMBL

A0A8L2UL38

Conserved Domains (1) summary

pfam07092
Location:27 → 221

DUF1356; Protein of unknown function (DUF1356)
XM_039085622.2 → XP_038941550.1 transmembrane protein 106A isoform X1

UniProtKB/TrEMBL

A0A8L2UL38

Conserved Domains (1) summary

pfam07092
Location:27 → 221

DUF1356; Protein of unknown function (DUF1356)
XM_063268741.1 → XP_063124811.1 transmembrane protein 106A isoform X1

UniProtKB/TrEMBL

A0A8L2UL38
XM_063268743.1 → XP_063124813.1 transmembrane protein 106A isoform X2

UniProtKB/Swiss-Prot

Q5BK83

UniProtKB/TrEMBL

A6HJD7
XM_063268742.1 → XP_063124812.1 transmembrane protein 106A isoform X2

UniProtKB/Swiss-Prot

Q5BK83

UniProtKB/TrEMBL

A6HJD7

Related

ENSRNOP00000036228.6, ENSRNOT00000035523.6