U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Lztr1 leucine zipper like post translational regulator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360745, updated on 3-Dec-2024

    Summary

    Official Symbol
    Lztr1provided by RGD
    Official Full Name
    leucine zipper like post translational regulator 1provided by RGD
    Primary source
    RGD:1309100
    See related
    EnsemblRapid:ENSRNOG00000001870 AllianceGenome:RGD:1309100
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in negative regulation of Ras protein signal transduction and protein ubiquitination. Predicted to be located in recycling endosome membrane. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); glioblastoma; hepatocellular carcinoma; neurilemmoma; and schwannomatosis (multiple). Orthologous to human LZTR1 (leucine zipper like post translational regulator 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 134.2), Brain (RPKM 131.8) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Lztr1 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96991956..97008127, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83487717..83503896, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87381638..87397849)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 74B Neighboring gene translation machinery-associated protein 16 pseudogene Neighboring gene THAP domain containing 7 Neighboring gene AIF family member 3 Neighboring gene CRK like proto-oncogene, adaptor protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endomembrane system ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    leucine-zipper-like transcriptional regulator 1
    Names
    leucine-zipper-like transcription regulator 1
    leucine-zipper-like transcriptional regulator, 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108326.2NP_001101796.1  leucine-zipper-like transcriptional regulator 1

      See identical proteins and their annotated locations for NP_001101796.1

      Status: PROVISIONAL

      Source sequence(s)
      BC169071
      UniProtKB/TrEMBL
      A0A8I5Y0T3, A6JSL5, B5DFI4, F7FP96
      Related
      ENSRNOP00000082766.2, ENSRNOT00000101549.2
      Conserved Domains (6) summary
      PLN02153
      Location:65347
      PLN02153; epithiospecifier protein
      sd00038
      Location:65111
      Kelch; KELCH repeat [structural motif]
      cd18308
      Location:417568
      BTB1_POZ_LZTR1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)
      cd18309
      Location:644769
      BTB2_POZ_LZTR1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)
      cd18505
      Location:572630
      BACK1_LZTR1; first BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)
      cd18506
      Location:765825
      BACK2_LZTR1; second BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      96991956..97008127 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248707.5XP_006248769.1  leucine-zipper-like transcriptional regulator 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y0T3
      Related
      ENSRNOP00000002554.6, ENSRNOT00000002554.8
      Conserved Domains (6) summary
      smart00225
      Location:665762
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd14821
      Location:571631
      SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
      sd00038
      Location:65111
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:662761
      BTB; BTB/POZ domain
      pfam01344
      Location:280323
      Kelch_1; Kelch motif
      pfam13415
      Location:74123
      Kelch_3; Galactose oxidase, central domain
    2. XM_039088534.2XP_038944462.1  leucine-zipper-like transcriptional regulator 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y0T3
      Conserved Domains (7) summary
      PLN02153
      Location:31278
      PLN02153; epithiospecifier protein
      sd00038
      Location:4695
      Kelch; KELCH repeat [structural motif]
      cd18308
      Location:291442
      BTB1_POZ_LZTR1; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)
      cd18309
      Location:518643
      BTB2_POZ_LZTR1; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)
      cd18505
      Location:446504
      BACK1_LZTR1; first BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)
      cd18506
      Location:639674
      BACK2_LZTR1; second BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1)
      pfam13415
      Location:154
      Kelch_3; Galactose oxidase, central domain
    3. XM_063270661.1XP_063126731.1  leucine-zipper-like transcriptional regulator 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y0T3