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    Ncapd2 non-SMC condensin I complex, subunit D2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362438, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ncapd2provided by RGD
    Official Full Name
    non-SMC condensin I complex, subunit D2provided by RGD
    Primary source
    RGD:1562596
    See related
    EnsemblRapid:ENSRNOG00000055300 AllianceGenome:RGD:1562596
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562596
    Summary
    Predicted to enable histone binding activity. Predicted to be involved in chromosome condensation; positive regulation of chromosome condensation; and regulation of chromosome segregation. Predicted to be located in cytosol and nucleus. Predicted to be part of condensin complex. Predicted to be active in condensed chromosome, centromeric region. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to human NCAPD2 (non-SMC condensin I complex subunit D2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 230.7), Spleen (RPKM 144.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ncapd2 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159655051..159677938, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157968814..157992314, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157682855..157705903, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene intermediate filament family orphan 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase Neighboring gene small Cajal body-specific RNA 10 Neighboring gene mitochondrial ribosomal protein L51 Neighboring gene vesicle-associated membrane protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a chromosome-targeting domain in the human condensin subunit CNAP1/hCAP-D2/Eg7. Ball AR Jr, et al. Mol Cell Biol, 2002 Aug. PMID 12138188, Free PMC Article
    2. Differential regulation of maternal and paternal chromosome condensation in mitotic zygotes. Bomar J, et al. J Cell Sci, 2002 Jul 15. PMID 12082153
    3. Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis. Martin CA, et al. Genes Dev, 2016 Oct 1. PMID 27737959, Free PMC Article
    4. Chromosome condensation by a human condensin complex in Xenopus egg extracts. Kimura K, et al. J Biol Chem, 2001 Feb 23. PMID 11136719
    5. Condensins I and II are essential for construction of bivalent chromosomes in mouse oocytes. Lee J, et al. Mol Biol Cell, 2011 Sep. PMID 21795393, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of chromosome separation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in condensed chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in condensed chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of condensin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of condensin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in pronucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    condensin complex subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399442.2 → NP_001386371.1  condensin complex subunit 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6ILS7
      Related
      ENSRNOP00000069882.3, ENSRNOT00000083016.3
      Conserved Domains (2) summary
      COG5098
      Location:185 → 1234
      COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
      pfam12922
      Location:75 → 240
      Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      159655051..159677938 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_575668.9 → XP_575668.6  condensin complex subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JWH3
      Conserved Domains (2) summary
      COG5098
      Location:185 → 1234
      COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
      pfam12922
      Location:75 → 240
      Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term

    2. XM_063286359.1 → XP_063142429.1  condensin complex subunit 1 isoform X3

    3. XM_039108815.2 → XP_038964743.1  condensin complex subunit 1 isoform X2

      Related
      ENSRNOP00000102742.1, ENSRNOT00000161204.1
      Conserved Domains (2) summary
      COG5098
      Location:147 → 1196
      COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
      pfam12922
      Location:37 → 202
      Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term

    4. XM_039108816.2 → XP_038964744.1  condensin complex subunit 1 isoform X5

      Conserved Domains (2) summary
      COG5098
      Location:67 → 1116
      COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
      pfam12922
      Location:1 → 122
      Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term

    5. XM_039108817.2 → XP_038964745.1  condensin complex subunit 1 isoform X6

      Conserved Domains (1) summary
      COG5098
      Location:1 → 626
      COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]

    6. XM_063286360.1 → XP_063142430.1  condensin complex subunit 1 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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