Fam98a family with sequence similarity 98, member A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fam98aprovided by RGD
Official Full Name: family with sequence similarity 98, member Aprovided by RGD
Primary source: RGD:1305486
See related: EnsemblRapid:ENSRNOG00000030328 AllianceGenome:RGD:1305486
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1305486
Summary: Predicted to enable protein methyltransferase activity. Predicted to be involved in several processes, including lysosome localization; positive regulation of ruffle assembly; and protein methylation. Predicted to be part of tRNA-splicing ligase complex. Orthologous to human FAM98A (family with sequence similarity 98 member A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 147.3), Muscle (RPKM 125.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (25626108..25640767)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (19874082..19888744)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (21051327..21065986)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in lysosome localization	IEA Inferred from Electronic Annotation more info
involved_in lysosome localization	ISO Inferred from Sequence Orthology more info
involved_in lysosome localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ruffle assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ruffle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ruffle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein methylation	ISO Inferred from Sequence Orthology more info
involved_in protein methylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of tRNA-splicing ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein FAM98A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014073.2 → NP_001014095.1 protein FAM98A

See identical proteins and their annotated locations for NP_001014095.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q5FWT1

UniProtKB/TrEMBL

A6H9W9

Related

ENSRNOP00000042004.4, ENSRNOT00000052131.4

Conserved Domains (1) summary

pfam10239
Location:11 → 327

DUF2465; Protein of unknown function (DUF2465)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

25626108..25640767

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063261850.1 → XP_063117920.1 protein FAM98A isoform X1
XM_039112160.2 → XP_038968088.1 protein FAM98A isoform X2

Conserved Domains (1) summary

pfam10239
Location:3 → 133

DUF2465; Protein of unknown function (DUF2465)