Ilvbl ilvB acetolactate synthase like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ilvblprovided by RGD
Official Full Name: ilvB acetolactate synthase likeprovided by RGD
Primary source: RGD:1307988
See related: EnsemblRapid:ENSRNOG00000028512 AllianceGenome:RGD:1307988
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable acetolactate synthase activity and flavin adenine dinucleotide binding activity. Predicted to be involved in L-valine biosynthetic process; fatty acid alpha-oxidation; and isoleucine biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of acetolactate synthase complex. Orthologous to human ILVBL (ilvB acetolactate synthase like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 177.3), Liver (RPKM 113.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (11690445..11700498, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (11039870..11049924, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (14044586..14054639, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acetolactate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables thiamine pyrophosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-valine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid alpha-oxidation	ISO Inferred from Sequence Orthology more info
involved_in isoleucine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of acetolactate synthase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 2-hydroxyacyl-CoA lyase 2

Names: acetolactate synthase-like protein; ilvB (bacterial acetolactate synthase)-like

NP_001102208.1

EC 2.2.1.-

XP_006241132.1

EC 2.2.1.-

XP_006241133.1

EC 2.2.1.-

XP_038935342.1

EC 2.2.1.-

XP_063119820.1

EC 2.2.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108738.1 → NP_001102208.1 2-hydroxyacyl-CoA lyase 2

See identical proteins and their annotated locations for NP_001102208.1

Status: PROVISIONAL

Source sequence(s)

CH474029

UniProtKB/TrEMBL

A6K931, A6K936, D4ACG2

Related

ENSRNOP00000036958.4, ENSRNOT00000039852.6

Conserved Domains (4) summary

cd07035
Location:96 → 249

TPP_PYR_POX_like; Pyrimidine (PYR) binding domain of POX and related proteins

PRK05858
Location:93 → 626

PRK05858; hypothetical protein; Provisional

cd02004
Location:487 → 660

TPP_BZL_OCoD_HPCL; Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL ...

pfam00205
Location:313 → 445

TPP_enzyme_M; Thiamine pyrophosphate enzyme, central domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

11690445..11700498 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006241071.5 → XP_006241133.1 2-hydroxyacyl-CoA lyase 2 isoform X1

See identical proteins and their annotated locations for XP_006241133.1

UniProtKB/TrEMBL

A6K934, A6K936

Conserved Domains (4) summary

cd07035
Location:56 → 209

TPP_PYR_POX_like; Pyrimidine (PYR) binding domain of POX and related proteins

PRK05858
Location:53 → 586

PRK05858; hypothetical protein; Provisional

cd02004
Location:447 → 620

TPP_BZL_OCoD_HPCL; Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL ...

pfam00205
Location:273 → 405

TPP_enzyme_M; Thiamine pyrophosphate enzyme, central domain
XM_006241070.5 → XP_006241132.1 2-hydroxyacyl-CoA lyase 2 isoform X1

See identical proteins and their annotated locations for XP_006241132.1

UniProtKB/TrEMBL

A6K934, A6K936

Conserved Domains (4) summary

cd07035
Location:56 → 209

TPP_PYR_POX_like; Pyrimidine (PYR) binding domain of POX and related proteins

PRK05858
Location:53 → 586

PRK05858; hypothetical protein; Provisional

cd02004
Location:447 → 620

TPP_BZL_OCoD_HPCL; Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL ...

pfam00205
Location:273 → 405

TPP_enzyme_M; Thiamine pyrophosphate enzyme, central domain
XM_063263750.1 → XP_063119820.1 2-hydroxyacyl-CoA lyase 2 isoform X1

UniProtKB/TrEMBL

A6K934

Related

ENSRNOP00000098968.1, ENSRNOT00000147763.1
XM_039079414.2 → XP_038935342.1 2-hydroxyacyl-CoA lyase 2 isoform X2

Conserved Domains (2) summary

PRK05858
Location:38 → 369

PRK05858; acetolactate synthase

cd02004
Location:230 → 403

TPP_BZL_OCoD_HPCL; Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL ...